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Example sentences for: bpti

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BPTI: Bovine Pancreatic Trypsine Inhibitor
The murinised version of ATF-BPTI differs by four amino acids from the human version It was shown to bind to the rat receptor and to inhibit plasmin activity in a rat model [ 21 ] . BPTI (commercialised as aprotinin) is a serine protease inhibitor prepared from bovine lung tissue which dose dependently inhibits human trypsin, plasmin and kallikrein.
BPTI: Bovine Pancreatic Trypsin Inhibitor
Systemic and local delivery of an adenovirus encoding ATF have been shown to inhibit the growth of primary tumour implants as well as of tumour metastasis in different animal models [ 18 19 ] . In the ATF-BPTI chimeric protein, ATF has two functions (1) the anti uPA effect with its known angiostatic activity and (2) delivery of BPTI at the tumour site due to over-expression of uPAR on tumour and endothelial cells.
Then a DNA fragment encoding the amino acids residues 36-96 of the bovine pancreatic trypsin inhibitor (BPTI) was cloned into the ATF plasmid resulting in a plasmid encoding the ATF, the BPTI and the 11 C-terminal amino acids of urokinase including the stop codon.