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Example sentences for: bpti

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BPTI: Bovine Pancreatic Trypsin Inhibitor
Systemic and local delivery of an adenovirus encoding ATF have been shown to inhibit the growth of primary tumour implants as well as of tumour metastasis in different animal models [ 18 19 ] . In the ATF-BPTI chimeric protein, ATF has two functions (1) the anti uPA effect with its known angiostatic activity and (2) delivery of BPTI at the tumour site due to over-expression of uPAR on tumour and endothelial cells.
BPTI has been used systemically in a few animal tumour models, and showed anti-tumour effects in a mouse hepatoma, lung carcinoma, and mammary carcinoma [ 22 23 24 ] , and in a fibrosarcoma of the hamster [ 24 ] . However, BPTI was not further developed as a systemic anti tumour agent probably because of its anti fibrinolytic property that might preclude its use in cancer patients.
BPTI: Bovine Pancreatic Trypsine Inhibitor