Words similar to bmal
Example sentences for: bmal
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At least 90 genes are regulated in a similar fashion by NPAS2:BMAL1 [ 37 ] and the identity of the target genes critical for the NREMS phenotype in cry1,2 -/- mice remains to be determined.
Recently, the search for components of the vertebrate circadian system has led to the identification of homologues of period [ 6, 7, 8, 9, 10, 11, 12] and timeless [ 13, 14, 15, 16], originally characterized as central clock genes in Drosophila , as well as Clock and Bmal1 ( Cycle ), identified initially in the mouse [ 17, 18, 19, 20, 21].
Albumin D-binding protein ( Dbp ) is a transcription factor whose expression is under the direct transcriptional control of CLOCK:BMAL1 [ 26 ] . Deletion of the dbp gene, which results in a shortening of the circadian period [ 35 ] , also results in decreased sleep consolidation and NREMS delta power [ 36 ] .
Finally, from a functional perspective, it is interesting that CLOCK/NPAS2:BMAL1 transcriptional activity is sensitive to redox state [ 24 ] . This transcriptional activity might thus provide a link between neuronal activity and an energy regulatory function for NREMS, as has been suggested previously [ 55 ] .
The high per levels in cry1,2 -/-mice and the low per levels in clock mutant mice [ 26 47 ] correlate with their contrasting sleep phenotype (see above; [ 34 ] ). In this context, the sleep abnormalities in dbp -/-mice might also be related to a reduction in per expression since, at least in vitro , DBP can amplify the CLOCK:BMAL1-induced transcription of per [ 48 ] , but it is not known whether per transcript levels are altered in dbp -/-mice.
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