Words similar to bmal
Example sentences for: bmal
How can you use “bmal” in a sentence? Here are some example sentences to help you improve your vocabulary:
At least 90 genes are regulated in a similar fashion by NPAS2:BMAL1 [ 37 ] and the identity of the target genes critical for the NREMS phenotype in cry1,2 -/- mice remains to be determined.
Recently, the search for components of the vertebrate circadian system has led to the identification of homologues of period [ 6, 7, 8, 9, 10, 11, 12] and timeless [ 13, 14, 15, 16], originally characterized as central clock genes in Drosophila , as well as Clock and Bmal1 ( Cycle ), identified initially in the mouse [ 17, 18, 19, 20, 21].
Interestingly, in the latter study rNoc was identified among a group of clock-regulated genes that included Per1 , Per2 , Per3 , Bmal1 , and D-binding protein ( DBP ). Independent clock driven pathways may be critical in the function of many tissues and organs as suggested by the widespread expression of clock genes in peripheral tissues [ 7, 8, 10, 11, 12].
Upon release into constant darkness cry1,2 -/-mice immediately become arrhythmic at the behavioral level [ 22 23 ] , at the level of SCN electrophysiology [ 28 ] , and at the cellular/molecular level [ 23 ] . Of the available mouse models for circadian dysfunction, only per1,2 double mutant mice [ 29 ] , bmal1 knockout mice [ 30 ] , and mice with an ablation of the SCN [ 31 ] show a similarly dramatic phenotype.
Albumin D-binding protein ( Dbp ) is a transcription factor whose expression is under the direct transcriptional control of CLOCK:BMAL1 [ 26 ] . Deletion of the dbp gene, which results in a shortening of the circadian period [ 35 ] , also results in decreased sleep consolidation and NREMS delta power [ 36 ] .
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