Words similar to bmal
Example sentences for: bmal
How can you use “bmal” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recently, the search for components of the vertebrate circadian system has led to the identification of homologues of period [ 6, 7, 8, 9, 10, 11, 12] and timeless [ 13, 14, 15, 16], originally characterized as central clock genes in Drosophila , as well as Clock and Bmal1 ( Cycle ), identified initially in the mouse [ 17, 18, 19, 20, 21].
A recent study in Drosophila melanogaster implicates transcriptional regulation by the circadian gene cycle , a homolog of the mammalian bmal1 gene, in the homeostatic regulation of rest [ 16 ] . While rest in flies shares several features with sleep in mammals [ 17 18 ] , it remains to be determined whether a similar role for BMAL1 or related transcriptional regulators is necessary for the homeostatic regulation of sleep.
Albumin D-binding protein ( Dbp ) is a transcription factor whose expression is under the direct transcriptional control of CLOCK:BMAL1 [ 26 ] . Deletion of the dbp gene, which results in a shortening of the circadian period [ 35 ] , also results in decreased sleep consolidation and NREMS delta power [ 36 ] .
Deletion of the cryptochromes disinhibits the transcriptional activation of CLOCK:BMAL1 and NPAS2:BMAL1 target genes, resulting in increased levels of their transcripts in the SCN, liver, and retina [ 20 23 25 ] . We assayed the expression in the brain of three genes that are known targets of cryptochrome mediated transcriptional inhibition: albumin D-binding protein ( dbp [ 26 ] ), period (per)1 , and per2 [ 20 23 27 ] , in the middle of the daily light period.
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