Words similar to blood-brain
Example sentences for: blood-brain
How can you use “blood-brain” in a sentence? Here are some example sentences to help you improve your vocabulary:
This finding suggests that the underlying abnormality is present at the luminal side of the blood-brain barrier (BBB) complex and is due to an abnormality of the cerebral vessels since it is unlikely that α-galactosidase A crosses the BBB to any appreciable extent.
Beyond the economics, for disorders of the central nervous system a small molecule with the potential to cross the blood-brain barrier would eliminate the need for injections directly into the brain, the current delivery mode for central nervous system protein therapies.
Thus, mefloquine apparently crosses the blood-brain barrier and accumulates to sufficient levels to include those concentrations found to disrupt neuronal calcium homeostasis and ER function in vitro . The possibility that a disruption of neuronal calcium homeostasis or ER function may be responsible, at least in part, for the clinical neurotoxicity of mefloquine is worthy of further investigation.
Clozapine is metabolized mainly at the liver resulting in several metabolites [ 5 14 ] . One of the major metabolites, N-desmethylclozapine has been shown to have pharmacological activity both in vitro [ 28 ] and in vivo in rats [ 29 ] . In addition, N-desmethylclozapine is found in large concentrations in the serum of schizophrenic patients [ 5 15 ] and in rats [ 30 ] . The contribution of N-desmethylclozapine to clozapine's central effects has been questioned recently, since the levels of N-desmethylclozapine in the brain were much lower than those of clozapine [ 30 ] suggesting that N-desmethylclozapine does not cross the blood-brain barrier as readily as clozapine.
Although at the present time it is difficult to comment on the pathophysiological significance of increased MMP-9 release, it is perhaps noteworthy that increased MMP-9 expression has been correlated with increased apoptosis [ 52 ] and increased microvascular permeability [ 53 ] , events possibly involved in the opening of the blood-brain barrier [ 54 ] and potential injury to the brain [ 50 ] .
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