Words similar to blood-brain
Example sentences for: blood-brain
How can you use “blood-brain” in a sentence? Here are some example sentences to help you improve your vocabulary:
Beyond the economics, for disorders of the central nervous system a small molecule with the potential to cross the blood-brain barrier would eliminate the need for injections directly into the brain, the current delivery mode for central nervous system protein therapies.
Thus, mefloquine apparently crosses the blood-brain barrier and accumulates to sufficient levels to include those concentrations found to disrupt neuronal calcium homeostasis and ER function in vitro . The possibility that a disruption of neuronal calcium homeostasis or ER function may be responsible, at least in part, for the clinical neurotoxicity of mefloquine is worthy of further investigation.
Mefloquine has been found to alter calcium flux, into and out of, isolated skeletal muscle and brain microsomes, via an inhibitory effect of the compound on the ER calcium pump and calcium release channels (IC 50 of 42-43 uM, [ 27 28 ] ). Plasma mefloquine concentrations (therapeutic dosing) may reach 21 μM [ 18 ] and the drug crosses the blood-brain barrier, accumulating to concentrations in excess of 50 and 90 μM in the brains of humans and rats respectively [ 19 20 ] . Therefore, these biochemical effects occur at concentrations within a relevant physiological range.
Clozapine is metabolized mainly at the liver resulting in several metabolites [ 5 14 ] . One of the major metabolites, N-desmethylclozapine has been shown to have pharmacological activity both in vitro [ 28 ] and in vivo in rats [ 29 ] . In addition, N-desmethylclozapine is found in large concentrations in the serum of schizophrenic patients [ 5 15 ] and in rats [ 30 ] . The contribution of N-desmethylclozapine to clozapine's central effects has been questioned recently, since the levels of N-desmethylclozapine in the brain were much lower than those of clozapine [ 30 ] suggesting that N-desmethylclozapine does not cross the blood-brain barrier as readily as clozapine.
This finding suggests that the underlying abnormality is present at the luminal side of the blood-brain barrier (BBB) complex and is due to an abnormality of the cerebral vessels since it is unlikely that α-galactosidase A crosses the BBB to any appreciable extent.
Loading...