Words similar to blockage
Example sentences for: blockage
How can you use “blockage” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cellulose acetate phthalate (CAP) is a promising microbicide candidate for prevention of infection by sexually transmitted disease (STD) pathogens, including HIV-1 [ 1 2 3 4 5 6 7 ] . CAP inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120, while leaving the site for the primary cellular receptor CD4 accessible [ 8 9 ] Soluble CD4 (sCD4) was shown to inhibit HIV-1 infection by two mechanisms: reversible blockage of virus binding to receptors, and irreversible inactivation of virus infectivity [ 10 ] . Since CAP and sCD4 bind to distinct domains on the HIV-1 envelope, it was of interest to determine whether or not these two ligands affect virus infectivity synergistically as do other combinations of anti-HIV-1 drugs and sCD4 [ 11 12 ] Binding of sCD4 leads to conformational changes in gp120 [ 13 14 15 16 17 ] . Binding of gp120 to coreceptors CXCR4 and CCR5, respectively, triggers additional conformational changes in HIV-1 envelope glycoproteins [ 18 19 ] For these reasons it was of interest to determine whether a) pretreatment of HIV-1 with sCD4 would affect subsequent binding of CAP to virus particles, and b) CAP binding to virus particles in the presence or absence of sCD4 would elicit conformational changes which could affect HIV-1 infectivity.
Thus, a blockage of HsN3 assembly resulted from deleting the prosequence of HsN3 allows the detection of a stable complex between Smad1 and HsN3 assembly intermediates.
The different effects of the isolated DBD on G1 and S blockage indicated that C/EBPα regulation of G1 and S phase arrest was mechanistically distinct.
This may be particularly important in differentiated, non-proliferating cells in which events that regulate a transcription factor's contribution to gene expression must be disconnected from that transcription factor's continuing blockage of proliferation.
A G1 block has been reported previously in C/EBPα-expressing mouse L cells [ 26 ] . However, those studies did not define the activities within C/EBPα required for that blockage.
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