Words similar to blockage
Example sentences for: blockage
How can you use “blockage” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since we have shown that artificial removal of the prosequence of HsN3 leads to a blockage of the normal assembly of HsN3 into the mature proteasome (Fig.
Despite the use of unlabeled polyA as a blocking agent, when microarray hybridization results obtained using probes derived from mRNA from two different sources are nearly the same, one cannot be certain that the similarity of the results is due to the similarity of the different mRNA source material, rather than to incomplete blockage of the polyA effect in both of the hybridizations.
Cellulose acetate phthalate (CAP) is a promising microbicide candidate for prevention of infection by sexually transmitted disease (STD) pathogens, including HIV-1 [ 1 2 3 4 5 6 7 ] . CAP inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120, while leaving the site for the primary cellular receptor CD4 accessible [ 8 9 ] Soluble CD4 (sCD4) was shown to inhibit HIV-1 infection by two mechanisms: reversible blockage of virus binding to receptors, and irreversible inactivation of virus infectivity [ 10 ] . Since CAP and sCD4 bind to distinct domains on the HIV-1 envelope, it was of interest to determine whether or not these two ligands affect virus infectivity synergistically as do other combinations of anti-HIV-1 drugs and sCD4 [ 11 12 ] Binding of sCD4 leads to conformational changes in gp120 [ 13 14 15 16 17 ] . Binding of gp120 to coreceptors CXCR4 and CCR5, respectively, triggers additional conformational changes in HIV-1 envelope glycoproteins [ 18 19 ] For these reasons it was of interest to determine whether a) pretreatment of HIV-1 with sCD4 would affect subsequent binding of CAP to virus particles, and b) CAP binding to virus particles in the presence or absence of sCD4 would elicit conformational changes which could affect HIV-1 infectivity.
Despite the use of this blocking procedure, when microarray hybridization results obtained using probes derived from mRNA from two different sources are nearly the same, one cannot be certain that the similarity of the results is due to the similarity of the different mRNA sources, rather than to incomplete blockage of the polyA effect in both of the hybridizations.
A G1 block has been reported previously in C/EBPα-expressing mouse L cells [ 26 ] . However, those studies did not define the activities within C/EBPα required for that blockage.
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