Words similar to biologic
Example sentences for: biologic
How can you use “biologic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Limitations of IL-1Ra as a pharmaceutical include its lack of oral availability and its short biologic half-life.
IL-1 has been implicated as a pathogenic mediator in numerous inflammatory and degenerative conditions, including rheumatoid arthritis (RA) and osteoarthritis (OA) [ 1 ] . The IL-1 receptor antagonist (IL-1Ra), a naturally occurring inhibitor of the biologic actions of IL-1, has obvious therapeutic potential in such diseases [ 2 ] ; indeed recombinant human IL-1Ra (anakinra) has recently been approved for use in patients with RA as the drug Kineret™ (Amgen, Inc., Thousand Oaks, CA, USA).
Future studies combining 5-FU with other cytotoxic / biologic compounds should consider the mechanism of the interaction and incorporate that information into the design of the trial.
Synovial tissues isolated from patients with rheumatoid arthritis (RA) display biologic properties that differ from 'normal' synovium, and there is a rapidly expanding catalogue of biochemical and molecular changes that underlie this phenotype [ 1 ] . We have investigated the feasibility of using Moloney murine leukemia virus (MoMLV) based vectors to constitutively express cloned genes in primary human fibroblast-like synovial cells (FLS), with the long-term objective of defining the contributions of specific signaling pathways and inflammatory mediators to the destructive phenotype of FLS in RA.
A similar vascular hyper-responsiveness has been noted in caveolin-1 knock-out mice [ 25 26 ] raising the possibility that the accumulation of Gb 3 results in over-activity of uncoupled endothelial nitric oxide synthase within endothelial cell caveolae generating superoxide and other reactive oxygen species [ 27 ] . The latter may have a vasodilatatory effect [ 28 ] . Predominance of vascular abnormalities in the vertebro-basilar system in Fabry disease suggests fundamental biologic differences between the anterior and the posterior circulation.
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