Example sentences for: bioavailability

How can you use “bioavailability” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The latter precursor has the advantage of small size and its activity is quite tolerant to derivatization at the para-position [ 22 ] , whereas the former is known to have high oral bioavailability and low toxic effects in rats [ 9 ] .

  • Compounds III with X = O, Y = H and OH in position 1, and compound II with X = S and Y = H were selected as the most promising candidates since their predicted oral bioavailability was among the highest while the potential harmful side effects were predicted to be low (Table 4).

  • Although we cannot eliminate the possibility of more subtle effects of chemopreventive agents on TGF-β bioavailability or cellular responsiveness, in our preliminary analyses we have seen no effects on the expression of type I and type II TGF-β receptors (data not shown).

  • M6P/IGF2R allelic loss would therefore result in enhanced cellular bioavailability of this potent growth factor, thereby potentially increasing both cell proliferation and resistance to apoptosis [ 29 ] . The M6P/IGF2R also facilitates the activation of TGFβ, a potent cell growth inhibitor that is secreted in an inactive form (reviewed in [ 15 16 ] ). M6P/IGF2R mutation is therefore one mechanism by which cancer cells can become refractory to TGFβ's mitoinhibitory effect.

  • Evaluating candidate molecules by the predicted pharmacokinetic parameters (Table 4) we favored those with higher oral bioavailability scores and lower urine excretion scores.


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