Words similar to bioavailability
Example sentences for: bioavailability
How can you use “bioavailability” in a sentence? Here are some example sentences to help you improve your vocabulary:
Fiber might affect the risk of breast cancer by decreasing estrogen levels; fiber binds estrogen excreted into the gastrointestinal tract and reduces enterohepatic circulation [ 17 18 ] . In addition, higher dietary fiber intake has been associated with higher plasma levels of sex-hormone-binding globulin, which can reduce the bioavailability of estrogens [ 19 ] . The potential mechanism of a protective effect of vegetable fat is more speculative: vegetable fat is a composite of multiple forms of fatty acids, some of which have been proposed to increase risk (such as C 18:2 n-6) whereas other specific fatty acids have been proposed to decrease risk (such as C 18:1 , the primary fatty acid in olive oil) [ 20 ] . More detail on the type and composition of the vegetable oil used is necessary to pursue this relation with greater precision.
In fact, activation of TGF-β requires the binding of latent TGF-β to the M6P/IGF2 receptor [ 11 ] . Therefore, down-regulation of M6P/IGF2R expression could also lead to a decreased bioavailability of activated TGF-β, thereby decreasing the sensitivity of MCF-7 cells to the TGF-β apoptotic pathway.
Although we cannot eliminate the possibility of more subtle effects of chemopreventive agents on TGF-β bioavailability or cellular responsiveness, in our preliminary analyses we have seen no effects on the expression of type I and type II TGF-β receptors (data not shown).
Compounds III with X = O, Y = H and OH in position 1, and compound II with X = S and Y = H were selected as the most promising candidates since their predicted oral bioavailability was among the highest while the potential harmful side effects were predicted to be low (Table 4).
Thus, they were tested against databases predicting plasma protein binding affinity [ 32 ] , oral bioavailability and urine excretion (unpublished results).
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