Example sentences for: bim

How can you use “bim” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, the PKC activation inhibitor, BIM, did not prevent either the PMA-induced hyperpolarization (Figs.

  • 7), supporting the hypothesis that activation of PKC synergizes secretory process activated by the glucose stimulation [ 3 4 5 ] . BIM is known to selectively inhibit α and β PKC isotypes [ 25 ] , and rat pancreatic β-cells possess at least one PKC isotype [ 2 ] . In fact, in this study, the treatment of islets with BIM reversed the PMA effect on insulin secretion (Fig.

  • The PMA effects with or without BIM on insulin secretion were measured by using immuno-reactive insulin (IRI) and stored at -20°C until the assay.

  • Recent work has shown that the Bcl-2 family regulates mitochondrial homeostasis during apoptosis [ 1 ] . Pro-apoptotic members, including Bax, Bak, Bid, and Bim, promote the release of death-inducing proteins, such as cytochrome c [ 2 3 ] , smac [ 4 ] , and endonuclease G [ 5 ] , from mitochondria while anti-apoptotic members, such as Bcl-2 and Bcl-X L , inhibit this release.

  • In two experiments, higher concentration (10 μM) of BIM failed to prevent PMA-induced inhibition too (data not shown).


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