Words similar to bim
Example sentences for: bim
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7), supporting the hypothesis that activation of PKC synergizes secretory process activated by the glucose stimulation [ 3 4 5 ] . BIM is known to selectively inhibit α and β PKC isotypes [ 25 ] , and rat pancreatic β-cells possess at least one PKC isotype [ 2 ] . In fact, in this study, the treatment of islets with BIM reversed the PMA effect on insulin secretion (Fig.
In the use of BIM, islets or cells were preincubated in the solution containing BIM (50 μM) for 30-60 min, and BIM was present in the bath solution throughout the experiment
Phorbol 12-myristate 13-acetate (PMA), 4a-phorbol 12,13-didecanoate (4a-PDD), bisindolylmaleimide (BIM) and NaCN were purchased from Sigma.
After pre-incubation for 60 min, islets were exposed to 1 μM BIM for 60 min, and then measured insulin secretion rate.
6panel E) were not significantly different between cells treated or untreated with BIM, activation of PKC seems to show little effect on K ATP , at least in this cell type.