Words similar to bifunctional
Example sentences for: bifunctional
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D. discoideum enzymes, MHCK-B [ 17 ] and MHCK-C (GenBank accession AAC31918, and [ 18 ] ). Several enzymes present in mammalian systems are now recognized as having the same conserved catalytic domain, including the eEF-2 kinases [ 19 ] [ 20 ] and TRP-PLIK, a bifunctional protein with kinase and ion channel activities [ 21 ] . Biochemical analysis with MHCK-B has confirmed that this enzyme phosphorylates D. discoideum myosin II in vitro [ 17 22 ] ). Analysis reported here confirms that MHCK-C also readily phosphorylates D. discoideum myosin II in vitro, supporting a possible direct role for this enzyme in myosin II localization control in vivo.
GSPS is a bifunctional enzyme: its synthase domain carries out the ATP-dependent fusion of two glutathione moieties to the polyamine spermidine to form the antioxidant metabolite GSP, while its amidase domain hydrolyzes the amide linkage to release glutathione and spermidine [ 26, 55, 56].
In C. elegans , two genes each encode unusual bifunctional enzymes containing both isocitrate lyase and malate synthase domains [ 49 ] . Since the isocitrate lyase domain lies within the amino-terminal half of the C. elegans bifunctional enzyme and none of the Meloidogyne EST reads stretches across both domains, further sequencing of the 3' end of cDNA clones from the M. hapla or M. javanica isocitrate lyase ESTs will be necessary to determine whether the Meloidogyne genus contains a bifunctional glyoxylate enzyme homolog similar to that of
These same organisms also possess AroQ•PheA bifunctional proteins whose AroQ domains also form a cohesive homology grouping.
When two paralogs of such a bifunctional gene are produced by duplication, each may be driven by positive selection to specialize in one of these functions, which it performs more efficiently than the ancestor gene, leading to the creation of two indispensable genes with distinct functions [ 11].
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