Example sentences for: benzimidazole

How can you use “benzimidazole” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our data does not support an interaction of this amino acid with either the N-benzyl or benzimidazole portions of lerisetron.

  • Functional groups on this compound capable of forming interactions with the receptor are the distal amino group, a benzimidazole and a benzyl group in the N1 position of the benzimidazole.

  • Recent studies have expanded on this model to include another lipophilic region and a second hydrogen bonding interaction two atoms away from the first [ 19 20 21 ] . A compound that contains all five pharmacophoric regions was synthesized by Orjales et al [ 22 ] . This compound (1-(phenylmethyl)-2-piperizinyl benzimidazole or lerisetron) is shown in figure 1and is a potent 5-HT 3 R antagonist.

  • In this study, we have endeavoured to identify the amino acids interacting with the different functional groups present on the lerisetron molecule in order to develop a model for interaction of this compound with the 5-HT 3 R. Using site directed mutagenesis in combination with analogs of lerisetron, we have identified amino acids that appear to interact selectively with the terminal amino group, the N-benzyl group and the aromatic benzimidazole.

  • W89 is shown interacting with the aromatic benzimidazole group of lerisetron although the precise position of W89 relative to this group is not known.


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