Words similar to benzimidazole
Example sentences for: benzimidazole
How can you use “benzimidazole” in a sentence? Here are some example sentences to help you improve your vocabulary:
The portion of the molecule common to all three compounds, the aromatic benzimidazole, is thus the most likely point of interaction for W89.
Our data does not support an interaction of this amino acid with either the N-benzyl or benzimidazole portions of lerisetron.
Recent studies have expanded on this model to include another lipophilic region and a second hydrogen bonding interaction two atoms away from the first [ 19 20 21 ] . A compound that contains all five pharmacophoric regions was synthesized by Orjales et al [ 22 ] . This compound (1-(phenylmethyl)-2-piperizinyl benzimidazole or lerisetron) is shown in figure 1and is a potent 5-HT 3 R antagonist.
Functional groups on this compound capable of forming interactions with the receptor are the distal amino group, a benzimidazole and a benzyl group in the N1 position of the benzimidazole.
The W89 interaction with this group is supported by the observed increase in K i for lerisetron, analog 1 and analog 2. Since the benzimidazole group is common to all three compounds it is the most likely point of interaction.