Words similar to bem
Example sentences for: bem
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Each contains an SH3 domain; a SAM (sterile alpha motif) domain; a proline-rich region, which mediates binding to the second SH3 domain of Bem1; and a PH domain [ 1 2 3 ] . Figure 1shows the relative positions of these sequence features in Boi1.
Other than the unidentified protease that acts on Boi1 in yeast extracts, the only proteins that we have evidence for binding to Boi1 are Bem1 and Cdc42, both of which show localization patterns similar to those for Boi1 ( [ 20 21 ] , and our unpublished data).
[ 26 ] Bem et al described a 31-year old German woman with a 'thyroid condition', who was also taking 'tranquillisers' (unspecified) and alcohol, and who had an acute exacerbation of her schizophrenia after a single tablet of mefloquine; her symptoms persisted for 4 weeks.
In particular, we wished to know whether either the SH3 domain or the proline-rich (Bem1-binding) region of Boi1 is important for any pattern of localization.
To address this issue, we used the following mutant versions of Boi1: the "S" mutant, which contains a Lys residue in place of a Trp residue at a highly conserved position in the SH3 domain; the "P" mutant, in which seven of the nine Pro residues in the Pro-rich region are replaced with Ala residues (a version of Boi1 that does not bind Bem1); and the "SP" mutant, which contains both the "S" and "P" changes [ 1 ] .