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Example sentences for: bem
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Each contains an SH3 domain; a SAM (sterile alpha motif) domain; a proline-rich region, which mediates binding to the second SH3 domain of Bem1; and a PH domain [ 1 2 3 ] . Figure 1shows the relative positions of these sequence features in Boi1.
To address this issue, we used the following mutant versions of Boi1: the "S" mutant, which contains a Lys residue in place of a Trp residue at a highly conserved position in the SH3 domain; the "P" mutant, in which seven of the nine Pro residues in the Pro-rich region are replaced with Ala residues (a version of Boi1 that does not bind Bem1); and the "SP" mutant, which contains both the "S" and "P" changes [ 1 ] .
For example, products of Ste18, Ste4, Cdc42, Cdc24, Far1, Bem1, Ste20, Ste5, and other proteins are thought to constitute a complex that has numerous interactions among components, and that mediates many different cellular processes [ 14 28 ] . The complex may coordinate mating pheromone detection with (1) cell cycle arrest via Far1p, (2) MAPK signal transduction via Ste5p and Ste20p, and (3) cell polarity via Bem1p and Far1p (among others) [ 29 30 ] .
The B em 1 - i nteracting proteins Boi1 and Boi2 were identified from screens for proteins that display two-hybrid interaction with the b ud- em ergence protein Bem1 [ 1 2 ] , a protein that is important for the initiation of budding and that contains two SH3 domains.
In particular, we wished to know whether either the SH3 domain or the proline-rich (Bem1-binding) region of Boi1 is important for any pattern of localization.
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