Words similar to bax
Example sentences for: bax
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We were also unable to detect Bax or Bcl-X L in rat adherent vascular lung neutrophils, which is in contrast to results with human peripheral blood neutrophils [ 30 31 ] . These differences may be due to unique attributes of human and rat cells, their distinct location in the vasculature, and/or to their exposure to inflammatory stimuli in vivo .
Additionally, since the identification and cloning of the p27 gene in 1994 [ 16 ] , the p27 protein has been shown to be involved in various other aspects of cell physiology and pathology [ 17 ] . Our previous study has shown, that differentiation of cells in tissue culture is associated with an increase in p27 expression [ 18 ] . Although a regular p27 expression protects normal cells from apoptosis, overexpression of p27 induces apoptosis of cells, through elevation of proapoptotic proteins, such as Bax [ 19 20 ] . These observations indicate that changes in p27 expression can determine the fate of muscle cells.
Recent work has shown that the Bcl-2 family regulates mitochondrial homeostasis during apoptosis [ 1 ] . Pro-apoptotic members, including Bax, Bak, Bid, and Bim, promote the release of death-inducing proteins, such as cytochrome c [ 2 3 ] , smac [ 4 ] , and endonuclease G [ 5 ] , from mitochondria while anti-apoptotic members, such as Bcl-2 and Bcl-X L , inhibit this release.
Apoptosis related molecules, such as Bcl-xS, Bax, and casepase-3, are known to be proapoptotic factors and involved in variety of vessel remodeling processes [ 37 38 39 ] . The initial arrest in Bcl-xS gene expression may momentarily depress apoptosis.
Though apoptosis in adult muscles has been described, and may result from changes within bcl2/bax system, alteration in pathways that regulate differentiation of muscle cells, changes in the myonuclei, and the nature of pathways inducing senescence of skeletal muscles are still far from being clear [ 14 ] .
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