Words similar to baclofen

Example sentences for: baclofen

How can you use “baclofen” in a sentence? Here are some example sentences to help you improve your vocabulary:

Preliminary reports have linked ligands active at the GABA receptor with SB or other NTDs, including benzodiazepines, alcohol, and zinc [ 7 8 9 10 11 ] . Preliminary work from this laboratory has shown the GABAa receptor agonist muscimol and the GABAb agonist baclofen produce both SB and the Arnold-Chiari malformation, commonly associated with SB [ 12 13 14 ] . VA appears to produce most of its anticonvulsant effects by increasing levels of GABA in the CNS, presumably by inhibiting the enzyme GABA-transaminase (GABA-T).
Previous work in this laboratory has demonstrated narrowing of the vertebral arch when zinc is co-administered with baclofen or muscimol [ 13 ] . It is unclear what the structural or functional consequence of vertebral arch narrowing is.
The GABAb agonist baclofen produced significant widening of the vertebral arch at 30 mg/kg (p < .05) but not at 15 or 60 mg/kg.
While the GABAa agonist muscimol and antagonist bicucullin widened the vertebral arch, as did the GABAb agonist baclofen, the GABAb antagonist hydroxysaclofen narrowed the vertebral arch.
Baclofen is a well-documented and specific GABAb agonist [ 34 ] .