Words similar to b-dna
Example sentences for: b-dna
How can you use “b-dna” in a sentence? Here are some example sentences to help you improve your vocabulary:
In giving her final seminar, she switched from her earlier insistence that B-DNA was nonhelical, but did not show the photo that gave the strongest evidence for helicity.
In January, Raymond Gosling gave to Wilkins the very well-oriented diffraction photo of B-DNA that he and Franklin had taken in July 1952.
In the former case, the DNA backbone sites located closest to one another are across the minor groove and separated in sequence by 3 bp [ 28 29 30 ] . The second proposal is supported by a recent 2.2 angstrom NarL-DNA structure for NarL-C-terminal domain complexed to a synthetic 7-2-7 NarL consensus binding site where the protein causes a conformational change of B-DNA to A-DNA (Ann Maris, personal communication).
CC-1065 (Figure 1) is among the most potent antitumor agents discovered [ 9 10 11 12 13 ] . It binds to double-stranded B-DNA within the minor groove with a sequence preference for 5'-d(A/GNTTA)-3' and 5'-d(AAAAA)-3', and alkylates the N3 position of the 3'-adenine with its left-hand CPI segment [ 14 15 ] . CC-1065 also inhibits gene transcription by interfering with binding of the TATA box-binding protein to its target DNA [ 16 ] . Despite its high potency and broad spectrum of antitumor activity, CC-1065 cannot be used in humans because it causes delayed death in experimental animals [ 17 ] . To pursue compounds possessing the potent antitumor activity but devoid of the toxic side effects of the parent compound, many CC-1065 analogues have been synthesized [ 18 19 20 21 22 23 24 25 26 ] .
They found a unique way to fit the bases in the structure by pairing, and by March 7 they had the double-helix model constructed: it obeyed the Chargaff ratios, it fit the X-ray data for B-DNA, and it provided a rational way to encode and transmit genetic information to subsequent generations.
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