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How can you use “aβ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • α-Secretase activation may explain how statins lower the risk for Alzheimer disease [69], since atorvastatin diminishes burden in plaque-forming transgenic mice [13].

  • Amyloidogenic (“amyloid generating”) cleavage by an enzyme called beta-secretase yields “sticky” peptides that aggregate to form deposits, whereas non-amyloidogenic cleavage by alpha-secretases generates soluble peptides that do not form deposits.

  • Monoclonal antibody 6E10 against residues 1–16 of human (Signet, Dedham, Massachusetts, United States) was used to detect human holoAPP or sAPP α . Anti-ROCK1 antibody was purchased from Chemicon (Temecula, California, United States).

  • Cao and Sudhof [56] have recently discovered that the APP C-terminal fragment generated by α- or β-secretase is itself cleaved to release and an APP intracellular domain (AICD) that diffuses into the nucleus, possibly acting there as a transcription factor.

  • Since atorvastatin has low blood–brain barrier permeability [71], this beneficial effect, if attributable to lowering, must be due to altered metabolism in the periphery.


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