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How can you use “aβ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Cao and Sudhof [56] have recently discovered that the APP C-terminal fragment generated by α- or β-secretase is itself cleaved to release and an APP intracellular domain (AICD) that diffuses into the nucleus, possibly acting there as a transcription factor.

  • These neurons receive monosynaptic input from Aδ and fibers.

  • Amyloidogenic (“amyloid generating”) cleavage by an enzyme called beta-secretase yields “sticky” peptides that aggregate to form deposits, whereas non-amyloidogenic cleavage by alpha-secretases generates soluble peptides that do not form deposits.

  • Amyloid deposits are composed of the amyloid-β peptide (), a 4-kDa peptide released during “amyloidogenic” proteolytic processing of the Alzheimer precursor protein (APP) [2].

  • sAPP α and sAPP β differ by the inclusion in sAPP α of the first 16 residues of .


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