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How can you use “aβ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Since atorvastatin has low blood–brain barrier permeability [71], this beneficial effect, if attributable to lowering, must be due to altered metabolism in the periphery.

  • To date, however, this mechanism is not supported by data from human clinical trials, where statin administration has shown no consistent effect on levels of circulating or cerebrospinal fluid [73].

  • This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain in plaque-forming transgenic mice.

  • Amyloid deposits are composed of the amyloid-β peptide (), a 4-kDa peptide released during “amyloidogenic” proteolytic processing of the Alzheimer precursor protein (APP) [2].

  • It is conceivable that, if statins lower circulating , this effect could secondarily cause diffusion of central nervous system interstitial down its concentration gradient and into the cerebrospinal fluid and circulation, from which it is cleared.


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