Example sentences for: aβ
How can you use “aβ” in a sentence? Here are some example sentences to help you improve your vocabulary:
α-Secretase activation may explain how statins lower the risk for Alzheimer disease [69], since atorvastatin diminishes Aβ burden in plaque-forming transgenic mice [13].
Amyloidogenic (“amyloid generating”) cleavage by an enzyme called beta-secretase yields “sticky” Aβ peptides that aggregate to form deposits, whereas non-amyloidogenic cleavage by alpha-secretases generates soluble peptides that do not form deposits.
Monoclonal antibody 6E10 against residues 1–16 of human Aβ (Signet, Dedham, Massachusetts, United States) was used to detect human holoAPP or sAPP α . Anti-ROCK1 antibody was purchased from Chemicon (Temecula, California, United States).
Cao and Sudhof [56] have recently discovered that the APP C-terminal fragment generated by α- or β-secretase is itself cleaved to release Aβ and an APP intracellular domain (AICD) that diffuses into the nucleus, possibly acting there as a transcription factor.
Since atorvastatin has low blood–brain barrier permeability [71], this beneficial effect, if attributable to Aβ lowering, must be due to altered Aβ metabolism in the periphery.