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How can you use “aβ” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • sAPP α and sAPP β differ by the inclusion in sAPP α of the first 16 residues of .

  • In cell culture, lovastatin and simvastatin decrease the release of by rat hippocampal neurons [12,14] while activating α-secretase-type ectodomain shedding [15,16].

  • α-Secretase-type ectodomain shedding divides the domain of APP, thereby generating α-secretase-cleaved soluble APP ectodomain (sAPP α ) [4].

  • Cao and Sudhof [56] have recently discovered that the APP C-terminal fragment generated by α- or β-secretase is itself cleaved to release and an APP intracellular domain (AICD) that diffuses into the nucleus, possibly acting there as a transcription factor.

  • Amyloidogenic (“amyloid generating”) cleavage by an enzyme called beta-secretase yields “sticky” peptides that aggregate to form deposits, whereas non-amyloidogenic cleavage by alpha-secretases generates soluble peptides that do not form deposits.


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