Example sentences for: aβ
How can you use “aβ” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since atorvastatin has low blood–brain barrier permeability [71], this beneficial effect, if attributable to Aβ lowering, must be due to altered Aβ metabolism in the periphery.
To date, however, this mechanism is not supported by data from human clinical trials, where statin administration has shown no consistent effect on levels of circulating or cerebrospinal fluid Aβ [73].
This proposal is supported by recent evidence that either genetic modification of ADAM-10/α-secretase activity [67] or administration of bryostatin, a PKC activator [68], can modulate levels of brain Aβ in plaque-forming transgenic mice.
Amyloid deposits are composed of the amyloid-β peptide (Aβ), a 4-kDa peptide released during “amyloidogenic” proteolytic processing of the Alzheimer Aβ precursor protein (APP) [2].
It is conceivable that, if statins lower circulating Aβ, this effect could secondarily cause diffusion of central nervous system interstitial Aβ down its concentration gradient and into the cerebrospinal fluid and circulation, from which it is cleared.