Words similar to avß

Example sentences for: avß

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Molecules that bind to avß3 integrin have also been used to target therapeutic compounds to tumors: compounds that antagonize this integrin can lead to apoptosis (programmed cell death) of cells that express it.
[ 18 F]Galacto-RGD has many of the features essential for a tracer: it is specifically accumulated by tumors that express avß3 integrin, it is efficiently eliminated by the kidneys, and it is stable in vitro and in vivo.
First, in a mouse with human melanoma they used highly sensitive positron emission tomography (PET) scanning to show not only that the level of uptake of integrin was specific for the tumor, but also that the uptake was in direct proportion to the amount of avß3 expressed, thus potentially allowing quantification of receptor expression; however, larger tumors showed a poorer correlation, possibly because of the presence of necrotic areas that do not express the integrin.
Haubner and colleagues, the authors of a paper in this month's PLoS Medicine , have previously developed a fluorine-labeled peptide, [ 18 F]Galacto-RGD, that has a high affinity for avß3 integrin.
avß3 integrin has a role in cell migration and extravasation, which occurs during metastasis, and also in angiogenesis—the development of new blood vessels that are essential for the growth of tumors.