Words similar to avp
Example sentences for: avp
How can you use “avp” in a sentence? Here are some example sentences to help you improve your vocabulary:
The behavioral effects of AVP are not limited to flank marking in hamsters.
The activation of flank marking is dose-dependent, and specific to AVP, as microinjections of other neuropeptides, excitatory amino acids, and catecholamines do not elicit the behavior [ 1 2 6 ] . Flank marking is also specific to AVP V1 receptors, as the behavior is selectively inhibited by V 1 receptor antagonists and activated by V1 receptor agonists [ 4 5 ] .
Indeed, alterations in AVP regulation and secretion are thought to be one possible biochemical abnormality in patients with Obsessive Compulsive Disorder (OCD) [ 15 16 17 18 ] . This disorder is characterized by sudden, recurrent thoughts or images that intrude into consciousness (obsessions) driving stereotyped acts that the person feels compelled to perform (compulsions) [ 19 ] . Interestingly, patients with OCD show elevated basal levels of AVP in the cerebrospinal fluid and exaggerated plasma levels of AVP in response to hypertonic challenge [ 16 ] . Many patients with anorexia nervosa and bulimia nervosa, both compulsive eating disorders, have abnormal levels of AVP in the cerebrospinal fluid and plasma [ 15 17 ] . Pediatric patients with severe OCD have low levels of AVP in cerebrospinal fluid, while a subgroup of pediatric patients with compulsive checking rituals has elevated AVP levels [ 18 ] . Hence, there are many clinical examples of compulsive behavior associated with a perturbation in the AVP system.
On the day of testing, animals were treated with clomipramine and 60-90 min later microinjected with 1.0 μM AVP in a volume of 100 nl and scored for flank marking and flank gland grooming.
Future studies could focus on effects of long-term elevation of AVP in hamsters; dose-response manipulations of psychotropics or clinical use of AVP receptor antagonists on humans to further investigate the role of AVP in OCD.
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