Words similar to autoregulatory

Example sentences for: autoregulatory

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Localization of this protein to the nucleus also mirrors that of endogenous PP1α in vivo . When using this system to forcibly overexpress 6His-HA-PP1α, there is a concomitant decrease in endogenous PP1α levels, suggesting the existence of an autoregulatory mechanism by which PP1α protein levels remain constant.
To address the possible autoregulatory mechanism(s) of PP1α expression and activity, we analyzed the RNA levels of both endogenous PP1α and induced 6His-HA-PP1α.
This putative autoregulatory mechanism for the catalytic subunit may help to explain why the overall abundance of PP1 during the various phases of the cell cycle remains relatively constant [ 32 ] . Historically, regulation of PP1 catalytic activity has resulted from associated subunits inhibiting or targeting the catalytic subunit towards substrates [ 33 ] . While the PP1 catalytic subunit is not found alone in the cell, such unassociated catalytic subunits have been shown to be active, at least in vitro . Although speculative, there may be a threshold amount of catalytic subunit in vivo above which associated proteins are limiting.
RT-PCR analyses of isolated polysome fractions supports the notion that this putative autoregulatory mechanism is exerted, at least in part, at the translational level.
This observation suggests that an as yet undescribed negative-feedback or autoregulatory mechanism exists for PP1α which contributes towards maintaining a constant level of this enzyme.