Words similar to autoregulatory
Example sentences for: autoregulatory
How can you use “autoregulatory” in a sentence? Here are some example sentences to help you improve your vocabulary:
Taken together, these data suggest that an as yet undescribed negative-feedback or autoregulatory mechanism exists for PP1α which contributes towards maintaining a constant level of protein expression and enzyme activity.
This putative autoregulatory mechanism for the catalytic subunit may help to explain why the overall abundance of PP1 during the various phases of the cell cycle remains relatively constant [ 32 ] . Historically, regulation of PP1 catalytic activity has resulted from associated subunits inhibiting or targeting the catalytic subunit towards substrates [ 33 ] . While the PP1 catalytic subunit is not found alone in the cell, such unassociated catalytic subunits have been shown to be active, at least in vitro . Although speculative, there may be a threshold amount of catalytic subunit in vivo above which associated proteins are limiting.
To guard against this scenario, control over the amount of PP1 catalytic subunit present via an autoregulatory mechanism would be beneficial.
Once IL-10 is produced it functions in an autoregulatory fashion to suppress proinflammatory cytokine mRNA expression and protein production [ 5 6 7 ] . In addition, IL-10 suppresses the expression of MHC class II molecules and costimulatory molecules such as intercellular adhesion molecule 1 and B7, leading to reduction in T-cell macrophage interactions [ 8 9 10 ] .
Just as is the case for PP2A [ 31 ] , it seems clear that efficient overall increases in PP1 protein abundance may not be achieved due to a putative negative feed-back or autoregulatory mechanism.
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