Example sentences for: autoregulatory

How can you use “autoregulatory” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To address the possible autoregulatory mechanism(s) of PP1α expression and activity, we analyzed the RNA levels of both endogenous PP1α and induced 6His-HA-PP1α.

  • Just as is the case for PP2A [ 31 ] , it seems clear that efficient overall increases in PP1 protein abundance may not be achieved due to a putative negative feed-back or autoregulatory mechanism.

  • This putative autoregulatory mechanism for the catalytic subunit may help to explain why the overall abundance of PP1 during the various phases of the cell cycle remains relatively constant [ 32 ] . Historically, regulation of PP1 catalytic activity has resulted from associated subunits inhibiting or targeting the catalytic subunit towards substrates [ 33 ] . While the PP1 catalytic subunit is not found alone in the cell, such unassociated catalytic subunits have been shown to be active, at least in vitro . Although speculative, there may be a threshold amount of catalytic subunit in vivo above which associated proteins are limiting.

  • This observation suggests that an as yet undescribed negative-feedback or autoregulatory mechanism exists for PP1α which contributes towards maintaining a constant level of this enzyme.

  • To guard against this scenario, control over the amount of PP1 catalytic subunit present via an autoregulatory mechanism would be beneficial.


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