Words similar to autoregulatory

Example sentences for: autoregulatory

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Taken together, these data suggest that an as yet undescribed negative-feedback or autoregulatory mechanism exists for PP1α which contributes towards maintaining a constant level of protein expression and enzyme activity.
Once IL-10 is produced it functions in an autoregulatory fashion to suppress proinflammatory cytokine mRNA expression and protein production [ 5 6 7 ] . In addition, IL-10 suppresses the expression of MHC class II molecules and costimulatory molecules such as intercellular adhesion molecule 1 and B7, leading to reduction in T-cell macrophage interactions [ 8 9 10 ] .
Precedent for an autoregulatory mechanism comes from a report by Baharians and Schonthal [ 31 ] , in which they demonstrate endogenous PP2A protein levels decrease in the presence of increasing amounts of forcibly-expressed exogenous PP2A.
Localization of this protein to the nucleus also mirrors that of endogenous PP1α in vivo . When using this system to forcibly overexpress 6His-HA-PP1α, there is a concomitant decrease in endogenous PP1α levels, suggesting the existence of an autoregulatory mechanism by which PP1α protein levels remain constant.
To address the possible autoregulatory mechanism(s) of PP1α expression and activity, we analyzed the RNA levels of both endogenous PP1α and induced 6His-HA-PP1α.