Example sentences for: autophosphorylation

How can you use “autophosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To test the function of the virally encoded receptors, we measured IGF-I stimulated autophosphorylation of the IGF-IR and phosphorylation of IRS-1.

  • Tie1 is an orphan receptor, whereas the ligands of Tie2 receptor have been identified as angiopoietin (Ang)-1 and Ang-2 [ 5 6 ] . Ang-1 has been shown to be responsible for recruiting and sustaining periendothelial support cells [ 7 ] . It has been reported that Ang-2 disrupts blood vessel formation in the developing embryo by antagonizing Ang-1-induced autophosphorylation of Tie2 [ 6 ] . Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and sprouting of blood vessels [ 7 8 ] . The physiologic roles of the Tie2 receptor and its ligands are limited to angiogenic processes that occur subsequently to the earlier vasculogenic and angiogenic actions of vascular endothelial growth factor (VEGF) and its receptors [ 7 ] . VEGF and the Tie family orchestrate optimal blood vessel formation [ 9 10 ] .

  • This level of regulation could be mediated via second messenger control of autophosphorylation, or via direct MHCK-C phosphorylation by other kinases.

  • The major autophosphorylation site in Btk maps to Y223 within the SH3 domain [ 24]; an analogous tyrosine is conserved in Rlk (Y91).

  • These results support the model that autophosphorylation activates MHCK-C.


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