Words similar to autophosphorylation
Example sentences for: autophosphorylation
How can you use “autophosphorylation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Tie1 is an orphan receptor, whereas the ligands of Tie2 receptor have been identified as angiopoietin (Ang)-1 and Ang-2 [ 5 6 ] . Ang-1 has been shown to be responsible for recruiting and sustaining periendothelial support cells [ 7 ] . It has been reported that Ang-2 disrupts blood vessel formation in the developing embryo by antagonizing Ang-1-induced autophosphorylation of Tie2 [ 6 ] . Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and sprouting of blood vessels [ 7 8 ] . The physiologic roles of the Tie2 receptor and its ligands are limited to angiogenic processes that occur subsequently to the earlier vasculogenic and angiogenic actions of vascular endothelial growth factor (VEGF) and its receptors [ 7 ] . VEGF and the Tie family orchestrate optimal blood vessel formation [ 9 10 ] .
Mutation of a second tyrosine, equivalent to the putative autophosphorylation site of Btk, slightly reduces tyrosine phosphorylation and kinase activity of Rlk.
Hypothetically, in RA synovial tissue the dominating Ang-1 induces the Tie2 pathway, whereas in normal synovial tissue higher Ang-2 presence blocks Ang-1 binding to Tie2 and inhibits its autophosphorylation.
Btk:ER itself was inducibly phosphorylated upon 4-HT treatment, as measured by anti-phosphotyrosine blotting and by a phosphospecific antiserum that recognises the Y223 site of Btk autophosphorylation.
Phosphorylation of Y551 and a putative autophosphorylation site Y223 in the SH3 domain of Btk [ 23, 24] are observed following BCR activation, suggesting that these tyrosine phosphorylations are functionally important for antigen receptor signaling.
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