Words similar to autocrine
Example sentences for: autocrine
How can you use “autocrine” in a sentence? Here are some example sentences to help you improve your vocabulary:
The observed suppression of its expression in chondrocytes by IL-1β (Table 2, panel B) is consistent with a previous report in osteoblastic cells [ 44] and suggests that IL-1β may enhance cartilage degradation by blocking an essential autocrine signal for chondrocyte maturation and function.
An association between autocrine IL-6 and PCA has been known for some time [ 16 17 ] . The change in prostate cell phenotype from paracrine IL-6-stimulated to autocrine IL-6-stimulated is believed to be a contributing factor in the progression from benign hyperplasia to neoplasia [ 17 ] . IL-6 is also implicated in the development of cancer cell resistance to chemotherapy in PCA patients [ 18 19 ] . In other studies, a chimeric protein consisting of an anti-IL-6 Ab fused to Pseudomonas exotoxin was found to inhibit proliferation of prostate carcinoma cell lines [ 20 ] . Exogenous IL-6 activated androgen responsive gene expression in the absence of androgens in human LNCaP cells [ 21 ] . More work is needed to clarify the role of IL-6 in prostate neoplasia.
It is possible that exogenous or autocrine IL-6 is not required for constitutive STAT3 activation in NRP-154 cells.
An autocrine effect of conceptus estrogen synthesis has been suggested as filamentous conceptuses have greater gene expression for estrogen receptor β compared to its spherical and tubular counterparts [ 9 ] .
Various cytokines are also produced by biliary epithelial cells [ 14 ] . As biliary epithelial cells are capable of both producing and responding to cytokines, these cells may use cytokines for the autocrine/paracrine regulation of their own function as well as that of other cells.
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