Example sentences for: autocrine

How can you use “autocrine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Because the result could not always be predicted by a mathematic estimation, there is a possibility that cell-cell contacts and some autocrine/paracrine production in a culture may alter the microenvironment thus determine the cytotoxicity caused by H 2 O 2 . Since cells with lower density are more susceptible to oxidative stress, there is a possibility that a vicious cycle exists such that when an area of RPE loses some of the constituent cells by oxidative stress, the remaining cells will become even more vulnerable to this insult.

  • Recent work by Hasty and coworkers [ 3] has demonstrated that local expression of IL-1β by articular chondrocytes activates autocrine gene expression, which contributes to the pathogenesis of osteoarthritis (OA).

  • The role of hormones in this process is clear; however, new results indicate that autocrine/paracrine or growth factor mechanisms also have important roles.

  • Various cytokines are also produced by biliary epithelial cells [ 14 ] . As biliary epithelial cells are capable of both producing and responding to cytokines, these cells may use cytokines for the autocrine/paracrine regulation of their own function as well as that of other cells.

  • An autocrine effect of conceptus estrogen synthesis has been suggested as filamentous conceptuses have greater gene expression for estrogen receptor β compared to its spherical and tubular counterparts [ 9 ] .


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