Words similar to autocrine
Example sentences for: autocrine
How can you use “autocrine” in a sentence? Here are some example sentences to help you improve your vocabulary:
An association between autocrine IL-6 and PCA has been known for some time [ 16 17 ] . The change in prostate cell phenotype from paracrine IL-6-stimulated to autocrine IL-6-stimulated is believed to be a contributing factor in the progression from benign hyperplasia to neoplasia [ 17 ] . IL-6 is also implicated in the development of cancer cell resistance to chemotherapy in PCA patients [ 18 19 ] . In other studies, a chimeric protein consisting of an anti-IL-6 Ab fused to Pseudomonas exotoxin was found to inhibit proliferation of prostate carcinoma cell lines [ 20 ] . Exogenous IL-6 activated androgen responsive gene expression in the absence of androgens in human LNCaP cells [ 21 ] . More work is needed to clarify the role of IL-6 in prostate neoplasia.
Because the result could not always be predicted by a mathematic estimation, there is a possibility that cell-cell contacts and some autocrine/paracrine production in a culture may alter the microenvironment thus determine the cytotoxicity caused by H 2 O 2 . Since cells with lower density are more susceptible to oxidative stress, there is a possibility that a vicious cycle exists such that when an area of RPE loses some of the constituent cells by oxidative stress, the remaining cells will become even more vulnerable to this insult.
The observed suppression of its expression in chondrocytes by IL-1β (Table 2, panel B) is consistent with a previous report in osteoblastic cells [ 44] and suggests that IL-1β may enhance cartilage degradation by blocking an essential autocrine signal for chondrocyte maturation and function.
An autocrine effect of conceptus estrogen synthesis has been suggested as filamentous conceptuses have greater gene expression for estrogen receptor β compared to its spherical and tubular counterparts [ 9 ] .
Dog gallbladder epithelial cells demonstrated increased mucin secretion following TNF-α treatment [ 10 ] . In addition, exogenous TNF-α altered the absorptive properties of cultured human gallbladder epithelial cells [ 37 ] . It is therefore reasonable to suggest that TNF-α produced by gallbladder epithelial cells in response to LPS could affect cellular function in an autocrine manner.
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