Words similar to autocrine
Example sentences for: autocrine
How can you use “autocrine” in a sentence? Here are some example sentences to help you improve your vocabulary:
The observed suppression of its expression in chondrocytes by IL-1β (Table 2, panel B) is consistent with a previous report in osteoblastic cells [ 44] and suggests that IL-1β may enhance cartilage degradation by blocking an essential autocrine signal for chondrocyte maturation and function.
Recent work by Hasty and coworkers [ 3] has demonstrated that local expression of IL-1β by articular chondrocytes activates autocrine gene expression, which contributes to the pathogenesis of osteoarthritis (OA).
Transformation appears to involve autocrine stimulation as IGF-I production and secretion is increased in normal cells following transformation by SV40 T antigen, but the null cells cannot respond to the IGF-I so do not transform.
The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis (IPF) has recently evolved [ 1 2 ] . Lung fibroblasts respond, in vitro , to inflammatory cytokines by producing growth factors and collagen, resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition, activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines, in vitro , and hence, these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells, via paracrine and autocrine mechanisms, perpetuating the fibrotic process [ 2 ] .
Various cytokines are also produced by biliary epithelial cells [ 14 ] . As biliary epithelial cells are capable of both producing and responding to cytokines, these cells may use cytokines for the autocrine/paracrine regulation of their own function as well as that of other cells.
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