Words similar to auto-inhibitory

Example sentences for: auto-inhibitory

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Thus, it appears that the TPR domains of the primitive parasitic PP5 may be less auto-inhibitory that those of their higher eukaryotic counterparts.
Auto-inhibitory role of PfPP5 TPR: activation by polyunsaturated fatty acids
To identify whether PfPP5 is actually expressed in the parasite, cell-free extracts of the asynchronous erythrocytic stage parasites were subjected to standard chromatographic procedures that had been previously optimized for human PP5 [ 18 ] . Studies of mammalian PP5 have revealed that the TPR domain might act as an auto-inhibitory domain of the phosphatase activity, and that tryptic digestion of PP5 causes loss of the TPRs and concomitant stimulation of activity [ 19 20 21 ] . As described under Materials and Methods, the purification was in fact monitored by assaying for a trypsin-activated phosphatase with the assumption that PfPP5 may behave like mammalian PP5 in this regard [ 18 20 21 ] . As mentioned, the activity peaks always coincided with a ~69 kDa band in parallel Western analyses of the chromatographic fractions.
The auto-inhibitory domain is involved in inhibiting the enzyme activity in the absence of Ca 2+whereas the variable region at the amino terminus may account for their substrate specificity and/or localization [ 22].