Words similar to augments
Example sentences for: augments
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The involvement of Rho GTPases in regulating integrin dependent events such as leukocyte homotypic aggregation and in chemokine upregulation of integrin-mediated adhesion has recently been identified [ 18 19 ] . ADP-ribosylation of Rho in neutrophils by treatment with C3 not only inhibits cellular locomotion, but augments chemoattractant induced actin polymerization [ 20 21 ] . Moreover, inactivation of Rho in monocytic cells leads to accelerated formation of filopodia, and it has been proposed that Rho is a negative regulator of actin polymerization within this cell type [ 22 ] . Active Rho is also required for normal morphology, motility, and cytolytic activity of IL-2 activated NK cells [ 23 24 ] . We and others have demonstrated the importance of Rho in T lymphocyte activation [ 25 26 ] . Given the role played by Rho in the regulation of actin microfilaments in other cell types, and the indispensability of a functional actin cytoskeleton in lymphocyte motility and activation, it is of importance to study Rho's role in the regulation of T lymphocyte integrin function and maintenance of cytoskeletal organization.
Moreover, increasing the abundance of TRPC3 in cultured myotubes prolongs the period in which intracellular calcium is elevated following a depolarizing stimulus, sustains the transcription factor NFAT within the nucleus, and augments expression of NFAT-dependent target genes [40].
Although several laboratories reported that crosslinking CD5 on the surface augments T cells signaling by inducing calcium flux and enhancing mitogenic response [ 14, 15, 16], recent studies using CD5-deficient mice indicate that CD5 may be more important as a negative modulator of TCR and BCR signal transduction [ 17, 18].
Thus by inducing migration and interaction with EC, IL-12 regulates crucial determinants of NK cell recruitment in tissues [ 20 ] . It is believed that IL-12 plays an instrumental role in tilting the immune response in favor of T helper type 1 by generation of Th1 cells and consequently initiates CMI [ 28 ] . Since IL-12 enhances cytotoxicity and augments proliferation by antigen specific T cells and NK cells, IL-12 may facilitate antigen specific and nonspecific cytotoxic immune defense against intracellular pathogens such as M. tuberculosis . An intriguing property of IL-12 is its capacity to induce proliferation by cytolytic T cell only upon co-stimulation with antigen.
augments the incident response capabilities of federal agencies.
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