Words similar to atrophy
Example sentences for: atrophy
How can you use “atrophy” in a sentence? Here are some example sentences to help you improve your vocabulary:
The private network that coordinates most organ distribution opposes the shift, because of a fear that this change will atrophy local transplant centers by diverting organs to a handful of large regional ones, and also deny organs to people who can't travel.
Optic nerve atrophy, retinal ganglion cell death, and inner nuclear layer cell loss were detectable in central sections and sections containing optic nerve that were slightly off center.
AKXD28 mice similarly develop iris stromal atrophy, anterior synechiae, and IOP elevation (Figure 2).
Indeed, unlike the atrophy and cell-death of infected central nervous system [ 1 ] , cardiac [ 2 ] , or gastro-intestinal [ 3 ] parenchyma, aberrant cell-cycle progression of infected renal epithelium is a defining feature of HIV-associated nephropathy (HIVAN) [ 4 5 ] . Yet, the mechanisms are largely unknown whereby HIV-1 subverts the cell-cycle controls that normally maintain renal epithelial in G 0 . Nonetheless, several observations from in vitro and in vivo models of HIVAN pathogenesis suggest that HIV-1 expression itself may be a key pathogenic factor.
Long polyglutamine repeats have been found in a number of transcription factors [ 39 ] . Notably, the C-terminus of murine HMG-box protein SRY contains a large polyglutamine repeat region that is responsible for the sex-determining function of this protein [ 40 ] . However, a number of neurodegenerative disorders, such as Huntington disease and spinobulbar muscular atrophy, are also strongly associated with proteins containing a polyglutamine stretch [ 41 ] . Conformational change and protein misfolding in the expanded polyglutamine region is believed to be the molecular basis of the pathogenesis [ 42 ] . Whether the presence of polyglutamine repeats in the C-terminus of human TNRC9 is important for function or alternatively hinders its ability to form a functional protein remains to be determined.
Loading...