Words similar to atrophy
Example sentences for: atrophy
How can you use “atrophy” in a sentence? Here are some example sentences to help you improve your vocabulary:
5. In the absence of LIFR, muscle atrophy may be caused by GC induced alteration of metabolism, which leads to glycogen accumulation, inhibition of protein synthesis and stimulation of protein degradation [ 67 68 ] . Because low levels of RU486 can fully protect Lifr -/- fetal muscle from the late gestation GC surge, the balance between hormone function and muscle integrity appears both delicate and direct.
Iris stromal atrophy (ISA) involves a loss of complex iris structure due to loss of iris stroma.
Some of these theories propose atrophy or resorption of the mesenchyme as development progresses to create the structures and spaces important for aqueous drainage while others propose a reorganization of cells with no cell death or atrophy.
Long polyglutamine repeats have been found in a number of transcription factors [ 39 ] . Notably, the C-terminus of murine HMG-box protein SRY contains a large polyglutamine repeat region that is responsible for the sex-determining function of this protein [ 40 ] . However, a number of neurodegenerative disorders, such as Huntington disease and spinobulbar muscular atrophy, are also strongly associated with proteins containing a polyglutamine stretch [ 41 ] . Conformational change and protein misfolding in the expanded polyglutamine region is believed to be the molecular basis of the pathogenesis [ 42 ] . Whether the presence of polyglutamine repeats in the C-terminus of human TNRC9 is important for function or alternatively hinders its ability to form a functional protein remains to be determined.
Indeed, unlike the atrophy and cell-death of infected central nervous system [ 1 ] , cardiac [ 2 ] , or gastro-intestinal [ 3 ] parenchyma, aberrant cell-cycle progression of infected renal epithelium is a defining feature of HIV-associated nephropathy (HIVAN) [ 4 5 ] . Yet, the mechanisms are largely unknown whereby HIV-1 subverts the cell-cycle controls that normally maintain renal epithelial in G 0 . Nonetheless, several observations from in vitro and in vivo models of HIVAN pathogenesis suggest that HIV-1 expression itself may be a key pathogenic factor.
Loading...