Words similar to atcop
Example sentences for: atcop
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In contrast, the AtCOP1 NLS has been identified as a classic bipartite nuclear localization signal, consisting of 21 amino acids in the intermediate region of coiled-coil domain and the WD-40 domain [ [ 17 ] ; Fig 8].
Comparison of the subcellular localization signals uncovers clear distinctions between AtCOP1 and MmCOP1.
Notably, the corresponding site in AtCOP1 is within the mapped cytoplasmic localization sequence [ 17 ] . Moreover, the NLS must also be located within amino acids 71 to 270 of MmCOP1, since NES-mutated or LMB-treated N200 is nuclear localized (Fig 6B).
A partial cDNA clone homologous to AtCOP1 has been previously identified in mammals, containing all three conserved protein-protein interaction domains [ 20 ] . Remarkably, when expressed in plant cells, the mammalian COP1-reporter fusion protein exhibited a light-regulated nuclear localization pattern similar to AtCOP1 [ 20 ] . Although mammalian COP1 failed to rescue the Arabidopsis cop1 mutants, over-expression of the amino-terminal half of mammalian COP1 in Arabidopsis caused a dominant-negative phenotype, resembling the effect of over-expressing the corresponding fragment of AtCOP1 [ 20 21 ] .
GFP-N346 (amino acid 71-416) contains the RING finger, the coiled-coil domain, and the region corresponding to the AtCOP1 NLS [ 17 ] and is localized exclusively in the nucleus, forming distinctive nuclear speckles (Fig 5Aand 5B).