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Example sentences for: atcop
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It is worth noting that deletion constructs of AtCOP1 covering the corresponding region were found localized predominantly in the cytoplasm, distinct from the mouse GFP-N280 fusion proteins [ 17 ] .
The subcellular localization of AtCOP1 is regulated by light [ 14 ] , a feature that is critical for its function [ 4 29 ] . Interestingly, the localization of mammalian COP1 protein expressed in plant cells can also be regulated by light [ 20 ] , implicating a similar mechanism may operate for the nucleocytoplasmic partitioning of COP1 in mammalian cells.
COP10, which has been shown to interact with AtCOP1 in yeast two-hybrid experiment, encodes a ubiquitin conjugating enzyme (E2) variant [ 44 ] . The COP9 signalosome, an eight-subunit complex homologous to the lid subcomplex of the 26 S proteasome [ 45 ] , directly associates with SCF E3 complex and promotes deneddylation of the cullin subunit of SCF in both plant and animal cells [ 46 47 48 49 ] . The exact relationship between COP1 and the COP9 signalosome remains obscure; it is known, however, that in Arabidopsis the COP9 signalosome is required for COP1 to accumulate in the nucleus in the dark [ 29 ] . Although COP1 most likely plays a role in regulating protein degradation, attempts in reconstituting ubiquitination of HY5 by AtCOP1 have been unsuccessful.
Compared to AtCOP1, the predicted full-length MmCOP1 and HsCOP1 proteins contain unique N-terminal glycine-serine rich extensions of about 70 amino acids (Fig.
This finding is distinct from the observation for AtCOP1, which exists mainly as a homodimer [ 32 ] . In addition, the HsCOP1 complexes differ from the HsCOP9 signalosome complexes in size, as suggested by the different peak fractions (Fig 4).
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