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Example sentences for: atcop
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One explanation for these discrepancies between AtCOP1 and MmCOP1 is that during the course of evolution, the animal and the plant COP1 proteins have adopted different regulatory mechanisms and probably different physiological and developmental functions.
1) encodes a protein product that corresponds to the full-length AtCOP1, but without the ATG start codon at its 5' end [ 20 ] . Homology search against the updated public EST database with the 5' end sequence of the available partial MmCOP1 cDNA allowed the identification of human and mouse EST clones containing a predicted starting codon and a partial 5' UTR, and the subsequent construction of full-length MmCOP1 and HsCOP1 cDNAs (see Experimental procedures for details).
It is worth noting that deletion constructs of AtCOP1 covering the corresponding region were found localized predominantly in the cytoplasm, distinct from the mouse GFP-N280 fusion proteins [ 17 ] .
COP10, which has been shown to interact with AtCOP1 in yeast two-hybrid experiment, encodes a ubiquitin conjugating enzyme (E2) variant [ 44 ] . The COP9 signalosome, an eight-subunit complex homologous to the lid subcomplex of the 26 S proteasome [ 45 ] , directly associates with SCF E3 complex and promotes deneddylation of the cullin subunit of SCF in both plant and animal cells [ 46 47 48 49 ] . The exact relationship between COP1 and the COP9 signalosome remains obscure; it is known, however, that in Arabidopsis the COP9 signalosome is required for COP1 to accumulate in the nucleus in the dark [ 29 ] . Although COP1 most likely plays a role in regulating protein degradation, attempts in reconstituting ubiquitination of HY5 by AtCOP1 have been unsuccessful.
In AtCOP1, the sequence responsible for the cytoplasmic localization is mapped to the region bordering both the RING finger and the coiled-coil domain, composed of 110 amino acids [ [ 17 ] ; Fig 8].
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