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Example sentences for: atcop
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GFP-N346 (amino acid 71-416) contains the RING finger, the coiled-coil domain, and the region corresponding to the AtCOP1 NLS [ 17 ] and is localized exclusively in the nucleus, forming distinctive nuclear speckles (Fig 5Aand 5B).
On the other hand, the site responsible for speckle formation is mapped within the cytoplasmic localization signal in AtCOP1 [ [ 19 ] ; Fig 8].
Because of its role in mediating the degradation of HY5, HYH, and possibly other transcription factors in Arabidopsis [ 4 5 ] and the presence of a RING finger domain and a WD-40 domain, AtCOP1 has been proposed to function as a RING-finger type ubiquitination E3 ligase, by recruiting E2 through its RING-finger domain and binding to the substrates through the WD-40 repeats [ 4 43 ] . This hypothesis is also supported by the findings about other negative regulators of plant photomorphogenesis.
In AtCOP1, the sequence responsible for the cytoplasmic localization is mapped to the region bordering both the RING finger and the coiled-coil domain, composed of 110 amino acids [ [ 17 ] ; Fig 8].
This speculation would be consistent with the fact that the subcellular localization of AtCOP1 is regulated by light only in certain types of plant cells [ 14 ] . Furthermore, the protein fragments responsible for regulating subcellular localization of AtCOP1 are quite conserved in MmCOP1, which may explain why the mammalian COP1, when expressed in onion epidermal cells, can be regulated by light in a similar manner as AtCOP1 [ 20 ] . However, the same nuclear translocation signal of AtCOP1 has been used in all plant cell types examined [ 17 19 ] , which argue against the later hypothesis.
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