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Example sentences for: asbt
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The uptake of bile acids by the CHO.asbt cells was saturable with an apparent K m ranging between 22 to 25 μM (Figure 3C).
Colonies surviving the selection process were assayed for asbt activity and several clones showing a range of bile acid uptake activities were selected for further analysis.
In summary, the failure of CHO.asbt cells to tolerate taurine-conjugated bile acids has revealed the existence of a mechanism that may be specific for cells that normally metabolize bile acids.
This leaves the possibility that conjugated bile acids may activate the apoptotic cascade through Fas receptor in this cell line, as glycine-conjugated bile acids do in hepatocytes [ 25 ] . However, the activation of caspases does not require a specific kind of bile acid transporter since TCA is not toxic to McArdle RH-7777 cells irrespective of whether these cells internalize bile acids via ntcp or asbt.
35 cells to taurine-conjugated bile acids was a consequence of asbt expression.