Words similar to arrestin
Example sentences for: arrestin
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Two molecular loci recently have been implicated as potential modulators of GnRH receptor signaling: one is the receptor itself [ 23 ] , and the other is the G protein that transduces the signal generated by binding of the receptor to its agonist [ 9 ] . With respect to the former locus, G protein coupled receptor kinases (GRKs) act in an agonist-specific manner to phosphorylate intracellular regions of the receptor thus permitting β arrestin binding that sterically inhibits G protein association with the receptor [ 1 45 ] . We have reported previously that experimental expression of GRKs in GnRH receptor-expressing heterologous cells (COS-1) suppressed GnRH-stimulated IP 3 production, and that co-expression of GRK2 and β-arrestin 2 suppressed GnRH receptor signaling more than that of either alone [ 23 ] . Stronger evidence that the GRK/β arrestin paradigm may play a role in regulating GnRH receptor signaling is our recent finding that adenovirus-mediated gene transfer of GRK2 into normal pituitary gonadotropes suppressed GnRH-stimulated LH secretion and IP 3 production [ 31 ] . However, no evidence has been presented for a direct interaction between β-arrestin and the GnRH receptor.
Conversely, setting a more stringent threshold to 1.9-fold intensity difference decreased the gene sets by 25% and removed genes such as Arrestin2 and CG11798 (Figure 6d,6f).
Another notable but unexpected finding was that Arrestin 2, the metarhodopsin-binding protein, was expressed in all imaginal discs we tested, not only in eye discs.
The results of the current investigation as well as those presented earlier [ 31 ] nominate two molecular mechanisms as playing roles in setting the responsiveness level of GnRH receptor signaling; i.e., the RGS3 system acts at the G protein transducing step and the GRK/β arrestin system acts at the level of the receptor.
This distribution suggests that the Drosophila Arrestin 2 might function outside the visual system.
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