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Example sentences for: arrayoligoselector
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The latest version and complete source code for ArrayOligoSelector is freely available at [ 26].
To avoid selecting oligonucleotides with secondary complex structure, ArrayOligoSelector uses the Smith-Waterman algorithm with the PAM47 DNA matrix to calculate the optimal alignment score between the candidate oligonucleotide sequence and the reverse complement of that sequence [ 24].
For this reason, a user-defined %GC target range is used by ArrayOligoSelector such that the majority of the array elements will share a similar base composition and hybridization properties across the array.
ArrayOligoSelector helps ensure complete genome coverage and optimal array hybridization while avoiding several potential problems originating from the peculiar characteristics of the P. falciparum genome.
The initial setting of the GC content filter was set to 28% GC (73°C T m . Subsequently, with the release of additional sequence information, a new set of predictions was generated in April 2002 and an additional 1,025 oligonucleotides were selected using the upgraded version of ArrayOligoSelector.
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