Words similar to arachidonic
Example sentences for: arachidonic
How can you use “arachidonic” in a sentence? Here are some example sentences to help you improve your vocabulary:
AA arachidonic acid
Prostaglandin E 2 is a major cyclooxygenase metabolite of arachidonic acid which exerts diverse effects on vascular smooth muscle tone and epithelial solute transport via G-protein coupled receptors [ 1 2 ] . At least four distinct G-protein coupled PGE 2 receptors have been cloned: the EP 1 , EP 2 , EP 3 , and EP 4 [ 1 ] . Pharmacological studies suggest PGE 2 relaxes vascular smooth muscle through two of these receptors, the EP 2 and EP 4 receptors, which couple to cyclic-AMP generation [ 3 ] . In contrast, PGE 2 constricts other vascular smooth muscle through EP 3 receptors which inhibit cAMP generation via G i or EP 1 receptors which increase Ca 2+mobilization [ 3 ] . Although both EP 2 and EP 4 receptors relax smooth muscle, EP 2 receptors are uniquely sensitive to the agonists butaprost and AH13205 [ 3 4 ] . Previous studies have shown that PGE 2 increases the cAMP concentration in many tissues including kidney, intestine and uterus, but the relative contribution of EP 2 versus EP 4 receptors to these effects is incompletely defined [ 5 6 ] . Recent studies in mice with targeted disruption of these receptors have suggested an important role for EP2 receptor in regulating systemic hemodynamics.
Data on the percent of the total fatty acid composition for linoleic acid (LA), for arachidonic acid (AA), and for docosahexanoic acid (DHA) in the microsomal and in the mitochondrial fractions of tumor, of liver, and of colon after two weeks of dietary intervention both with and without sE supplementation are summarized in Table 1. The mean levels of LA were lower in both microsomal and mitochondrial fractions of the tumor, the liver, and the colon of mice fed sE than in mice without the sE.
Certain prostaglandins are required for female reproduction and kidney function [ 3 4 5 ] . Because of its important role in controlling levels of arachidonic acid (AA), much attention has been focused on the regulation of cPLA 2 activation, with particular emphasis on the role of its phosphorylation and Ca 2+-mediated translocation [ 6 7 8 ] .
NSAIDs work, at least in part, by inhibiting cyclo-oxygenase, the enzyme that converts arachidonic acid to prostaglandins.
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