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Example sentences for: aquateric
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Recombinant gp120 HIV-1 IIIB in the presence of a 10-fold excess of BSA and gelatin, respectively, was quantitated by adding the gp120/BSA/gelatin mixtures (before and after binding to micronized CAP or Aquateric; Fig.
The quantity of gp120 not adsorbed to CAP/Aquateric was determined from calibration curves relating absorbance readings to the concentration of gp120 not exposed to CAP/Aquateric.
To avoid this, CAP in micronized form (which does not aggregate at low pH), instead of CAP in soluble form is being considered as a topical microbicide [ 30 31 32 33 34 35 ] . Micronized CAP (Aquateric) was shown to be virucidal against HIV-1, herpesviruses and several nonviral sexually transmitted disease (STD) pathogens [ 30 31 32 33 34 ] . The virucidal activity of micronized CAP could at least partly be explained by its buffering capacity at low pH [ 40 ] since it is a free acid while other anionic polymeric microbicide candidates (except BufferGel, the active ingredient of which is Carbomer 974P [ 27 ] ) are sodium salts.
9997% of gp120 bound to micronized CAP and Aquateric (final concentration of CAP: 121.
In order to correlate the properties of CAP in soluble and micronized forms, it was necessary to establish whether or not micronized CAP would bind HIV-1 virus particles and HIV-1 envelope glycoproteins, and induce the formation of gp41 six-helix bundles, a marker of irreversible virus inactivation, as did soluble CAP [ 37 ] . First it was established that HIV-1 gp120 bound to micronized CAP (provided in the form of micronized CAP particles or of a commercial product, "Aquateric", containing about 66% of CAP and used for enteric coating of tablets and capsules in the pharmaceutical industry [ 54 ] ); (Fig.
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