Words similar to apobec

Example sentences for: apobec

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The genomes of primates contain a family of nine APOBEC genes that encode enzymes involved in the editing of RNA and/or DNA through the deamination of cytosine (C), so that this nucleotide mutates to uracil (U).
Two more enzymes, APOBEC3G and APOBEC3F, form part of the innate immune system; they function as antiviral agents and are being intensively studied in the context of infection with the human immunodeficiency virus (HIV), the cause of AIDS.
By increasing the rate at which deleterious mutations appear, APOBEC3G pushes viruses over this edge, causing a form of ‘lethal mutagenesis’ that results in their destruction; the rate of mutation becomes so high that no genome can reproduce itself faithfully, and the population crashes.
Although there is still some debate over exactly how APOBEC3G leads to viral eradication, the most likely scenario is that G3A hypermutation results in the generation and incorporation of a multitude of deleterious mutations that fatally disrupt viral functions.
Hence, it is probably only in naturally occurring Vif-defective mutants that APOBEC3G is effective against HIV.