Example sentences for: apobec

How can you use “apobec” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The discovery that a natural antiviral agent, APOBEC3G, probably works in much the same way should provide even more encouragement.

  • Given the frequency with which the remnants of past retroviral infections are found in the mammalian genome (Smit 1999), in the form of usually defunct endogenous retroviruses (Box 1), it is likely that our genomes are continually bombarded with retroviruses like HIV but that the majority are cleared by innate immune mechanisms like APOBEC3G.

  • Hence, it is probably only in naturally occurring Vif-defective mutants that APOBEC3G is effective against HIV.

  • APOBEC1, for example, is involved in the C→U editing of apolipoprotein B mRNA (therein christening the family), while another family member, the activation-induced deaminase, has a vital role in adaptive immunity in that it assists in the diversification of antibodies.

  • Although there is still some debate over exactly how APOBEC3G leads to viral eradication, the most likely scenario is that G3A hypermutation results in the generation and incorporation of a multitude of deleterious mutations that fatally disrupt viral functions.


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