Words similar to apobec

Example sentences for: apobec

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Furthermore, because positive selection on APOBEC3G has operated for at least 30 million years and lentiviruses in general, and HIV in particular, are likely to be more recently evolved than this, it is clear that a broad range of retroviral pathogens have been responsible for the adaptive evolution of this particular immune gene (Sawyer et al.
APOBEC3G-induced deamination at this stage results in monotonous guanine-to-adenine (G→A) nucleotide changes, a phenomenon called G→A hypermutation that had long been noted by HIV researchers without a clear understanding of its cause.
Although there is still some debate over exactly how APOBEC3G leads to viral eradication, the most likely scenario is that G3A hypermutation results in the generation and incorporation of a multitude of deleterious mutations that fatally disrupt viral functions.
The genomes of primates contain a family of nine APOBEC genes that encode enzymes involved in the editing of RNA and/or DNA through the deamination of cytosine (C), so that this nucleotide mutates to uracil (U).
The discovery that a natural antiviral agent, APOBEC3G, probably works in much the same way should provide even more encouragement.