Example sentences for: ap-site

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The importance of such bonds for activity was shown in other work, where huAPE1's binding to the DNA backbone is only inhibited by ethylation of the phosphates two and three positions 3' to an abasic site [ 18 ] . Mutation of R177A, at the end of Molego 6, that binds to this region and to the bases opposite the AP-site had enhanced activity [ 11 ] , while mutations at W280 (Molego 11) and F266 (Molego 10) [ 33 ] reduce activity and, in the latter case, substrate selectivity.
The extensive contacts that APE1 makes to these positions are mediated by molegos it does not share with DNase 1. Molegos 6, 7a and 10 all have residues within hydrogen bonding distance of the three basepairs 3' of the AP-site.

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