Example sentences for: ap-

How can you use “ap-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our experiments in a reconstituted transcription system lacking contaminating AP-1 proteins and using DNA templates with high affinity NFAT sites demonstrate that NFATp can function as a transcriptional activator on its own.

  • Along these lines, it has been shown that RSV activation of chemokine gene promoters involves multiple inducible transcription factors including AP-1 [ 52 53 ] , which is also a redox sensitive transcription factor important in chemokine gene expression [ 28 36 54 ] . AP-1 can also be inhibited by DEX and has been shown to cooperate with NF-κB to mediate RSV induction of IL-8 [ 46 55 ] .

  • This cohort of AP-1, Fos, and ets family members may also preferentially bind to different AP-1 sites in MMP promoters, with subtle effects on gene expression [ 32].

  • For example, PPARγ is involved in a positive feedback mechanism that induces the formation of foam cells [ 23 ] . On the other hand, activation of PPARγ was shown to inhibit monocyte [ 24 ] and macrophage [ 25 ] inflammatory responses by preventing the activation of nuclear transcription factors, such as NF-kB (nuclear factor-kappa B), AP-1 (activator protein-1) and STAT 1 (signal transducer and activator of transcription 1).

  • We first addressed this issue by transiently transfecting a heterologous promoter containing a consensus AP-1 site fused to the luciferase reporter gene [ 11 ] along with wild type RARα or S77A mutant expression vectors.


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