Example sentences for: ap-

How can you use “ap-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It was reported that PPAR activation could down-regulate the activity of AP-1 by interfering with the functions of c-jun [ 36 37 ] . Therefore, the following set of experiments was designed to test if PPAR activation could reduce c-jun activation in 25-OH-cholesterol treated microglia.

  • Activation of the JNK pathway can lead to the phosphorylation of downstream members including c-jun that belongs to the AP-1 transcription factor family [ 12 52 ] . Because results from this study indicated that JNK pathway was activated by 25-OH-cholesterol, one could expect that AP-1 would be activated in cells treated with cholesterol oxides.

  • Transcription factor genes that were modulated by IL-1β included members from the NF-κB family (relB, p100/p52, p105/p50, IκB-ε, c-rel, and p65), the AP-1 family (fra-1 and junB), and the ETS family (ets-1).

  • The MAPK acts by stimulating AP-1 and a subsequent physical and functional interaction of AP-1 with NF-κB, resulting in a complex that synergistically transactivates the HIV-1 [ 60 ] . At the level of infection and entry, the activation of MAPK through the Ras/Raf/MEK (MAPK kinase) signaling pathway enhances the infectivity of HIV-1 virions.

  • An analysis of the transcriptional properties unique to NFATp required the use of a reconstituted transcription system that is responsive to human NFATp, independent of AP-1 activity.


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