Words similar to antimalarial
Example sentences for: antimalarial
How can you use “antimalarial” in a sentence? Here are some example sentences to help you improve your vocabulary:
Rapid and accurate methods are needed for the diagnosis of Plasmodium falciparum malaria [ 1 2 ] as malaria is estimated to kill between 1.4 and 2.6 million people each year [ 1 ] . WHO South East Asian regional office estimates 19500 deaths due to malaria in India annually [ 3 ] . P. falciparum infections in children may become life threatening making rapid diagnosis of extreme importance [ 4 ] . No clinical diagnostic criteria are both sensitive and specific for malaria, an undifferentiated febrile illness [ 5 ] which may result in the erroneous treatment of millions of non-malaria cases with antimalarial drugs in the absence of diagnostic malaria microscopy.
In areas where mosquito abatement has failed, chemotherapy, consisting of a limited selection of antimalarial agents, is the only defense against this disease.
Excessive antimalarial drug use is costly, propels the emergence of drug resistant parasites, speeds the obsolescence of affordable drugs and retards malaria control [ 6 ] . Prompt diagnosis and effective treatment of malaria improves prognosis [ 2 ] . In the absence of diagnostic microscopy in resource poor, remote villages of tribal forested belt of central India, the detection of P. falciparum histidine rich protein 2 (Pf HRP-2) in a blood specimen is one method by which expeditious diagnosis of falciparum malaria can be made on the spot [ 7 8 ] . Recently introduced rapid malaria test, Determine™ malaria pf (Abbott Laboratories, Japan) have been evaluated for its effectiveness in detecting P. falciparum malaria in Philippines [ 9 ] and in central India [ 10 ] .
The structural and biochemical properties of PfPP5 described herein are hallmarks of the PP5 class, and thus establish PfPP5 as a likely player in parasitic signal transduction, and hence a potential target for antimalarial drug design.
Further understanding of cellular physiology of this parasite including basic metabolic functions and the intricate interactions between the parasite cell and human host immune system will be a key step in uncovering new targets for antimalarial drug discoveries and vaccine development.
Loading...