Example sentences for: antiapoptotic

How can you use “antiapoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Oxoguanine has become the benchmark for oxidative DNA modifications; it is arguably the most important mutagenic lesion in DNA (mispairing with adenine during chromosomal replications causes GC → TA transversions) [ 24 ] . It is suggested that untoward oxidative stresses to DNA prompt cell-cycle delay, antiapoptotic, and repair responses.

  • This increased activity of proapoptotic (caspase3/PARP) and compensatory antiapoptotic (ERK1/2) pathways is consistent with the dramatic cell death seen in SN50-treated SMGs.

  • Injured adult DRG neurons do not die after axonal injury [ 15 ] as a result of the upregulation of cell survival factors such as the small heat shock protein HSP27 [ 16 ] . We now find several genes that could have a survival-promoting role, including the peripheral benzodiazepine receptor, whose agonists are potent antiapoptotic compounds [ 17 ] , GADD45A, which maintains genomic stability and appears to be anti-apoptotic in neurons after ischemic damage [ 18 ] , metallothionein 1L, which is a free radical scavenger [ 19 ] , GTP cyclohydrolase 1, which is obligatory for the actions of NGF on PC12 cells [ 20 ] , and IES-JE (MCP-1) which attracts macrophages, which in turn have been reported to have a role in neuronal survival [ 21 ] .

  • IκBα is a physiological inhibitor of NF-κB activation; IκBα complexes with NF-κB and prevents its translocation to the nucleus [ 10 24 ] . NF-κB activation is believed to induce antiapoptotic proteins to block cell death [ 8 ] . However, in several studies activated NF-κB cannot protect cells from apoptosis [ 8 ] . Also, NF-κB appears to be essential in the p53-mediated apoptosis in tested cell lines [ 25 ] .

  • In contrast, TGF-β1 protects L929 cells from TNF cytotoxicity by upregulating the expression of antiapoptotic TIAF1, TIF2 and a novel matrix protein [ 11 12 13 14 ] . TGF-β1 blocks PH-20-increased TNF susceptibility [ 15 ] . Likewise, PH-20 inhibits TGF-β1-induced TNF-resistance [ 15 ] . TGF-β1 suppresses PH-20-mediated ERK activation [ 16 ] ; however, the ERK activation is not related with PH-20-increased TNF susceptibility in L929 cells [ 15 ] . Whether the proapoptotic p53 and WOX1 block the function of antiapoptotic TIAF1 and TIF2 is not known.


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