Words similar to anti-theophylline

Example sentences for: anti-theophylline

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The effector specificity could be rationally changed by changing the specificity of the conjoined aptamer: when a mutation was introduced into the anti-theophylline aptamer that led to discrimination against theophylline and in favor of 3-methylxanthine (that also differed from theophylline by a single methyl group), the aptamer became solely responsive to 3-methylxanthine in vivo . Group I aptazymes may have a number of important biotechnology applications, including use as in vivo , real-time reporters and as regulatable gene therapeutics.
In order to examine effector-specificity in vivo , a new series of Group I aptazymes was constructed in which the anti-theophylline aptamer was mutated to bind 3-methylxanthine (3MeX2P6) [ 34 ] . These variants proved to be responsive to 3-methylxanthine both in vitro and in vivo (Figure 6a).
, 7-methyltheophylline); the anti-theophylline aptamer is known to discriminate between caffeine and theophylline by a factor of 10,000-fold [ 10 ] . No effector-dependent growth differences were observed with cultures containing
Based on these studies, we designed a series of Group I aptazymes in which the anti-theophylline aptamer was substituted for either a portion of P6 or P5 (Figure 1).
The ligand specificity of the anti-theophylline aptamer carried over to the theophylline-dependent aptazyme, and no activation was seen with caffeine, which differed by a single methyl group from theophylline.