Words similar to anti-theophylline

Example sentences for: anti-theophylline

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The effector specificity could be rationally changed by changing the specificity of the conjoined aptamer: when a mutation was introduced into the anti-theophylline aptamer that led to discrimination against theophylline and in favor of 3-methylxanthine (that also differed from theophylline by a single methyl group), the aptamer became solely responsive to 3-methylxanthine in vivo . Group I aptazymes may have a number of important biotechnology applications, including use as in vivo , real-time reporters and as regulatable gene therapeutics.
The ligand specificity of the anti-theophylline aptamer carried over to the theophylline-dependent aptazyme, and no activation was seen with caffeine, which differed by a single methyl group from theophylline.
Based on these studies, we designed a series of Group I aptazymes in which the anti-theophylline aptamer was substituted for either a portion of P6 or P5 (Figure 1).
The anti-theophylline aptamer was attached at the same point as had previously proven successful in the design of theophylline-dependent cleavases and ligases [ 13 14 ] .
, 7-methyltheophylline); the anti-theophylline aptamer is known to discriminate between caffeine and theophylline by a factor of 10,000-fold [ 10 ] . No effector-dependent growth differences were observed with cultures containing