Words similar to anti-proliferative
Example sentences for: anti-proliferative
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Our finding that 24 h exposure to 4-AP decreased the number of viable GC in serum-free but not serum-supplemented primary cultures is consistent with the reported effects of 4-AP and other K +channel antagonists on other cell types [ 8 43 44 ] . It has been shown that the concentrations of K +channel antagonists required to inhibit growth of human bladder tumor cells can be 70 times higher in the presence than the absence of serum [ 43 ] . 4-AP has been shown to inhibit the proliferation of human myelobastic leukemia cells by preventing growth factor activation of mitogen activated protein kinase (MAPK) pathways [ 42 ] . This mechanism may be responsible for the anti-proliferative effect of 4-AP manifest in Table 1. It is likely that MAPK pathways are less robust in GC grown in defined serum-free vs. serum-supplemented media; however, validation of this hypothesis would require additional experiments beyond the scope of the present investigation.
The anti-proliferative effects of C/EBPα do not require activities in C/EBPα commonly required for gene-specific transcription.
These domains interact with p21, CDK2 and CDK4 [ 22 24 25 36 55 ] . Thus, C/EBPα interactions with at least p21 and CDK4 were not required for the anti-proliferative actions of C/EBPα in GHFT1-5 cells.
The myeloblastin protein displays anti-proliferative properties and is also a key protease involved in factor-independent growth of hematopoietic cells [ 18 ] . Overexpression of myeloblastin has been linked to multifunctional cytokine transforming growth factor-β (TGF-β) a known regulator of angiogenesis.
Androgen is essential for normal prostate function, but has also been implicated in the pathogenesis and neoplasia of prostate cancer [ 1 2 26 ] . On the other hand, retinoid is essential for normal prostate function [ 7 27 28 ] and exhibits anti-proliferative and chemopreventive efficacy in experimental prostate carcinoma [ 8 9 10 ] . The dose-dependent stimulation of 3H-thymidine incorporation in LNCaP cells by T and RA when administered alone, and reciprocal suppression of such effects by each other, are consistent with previous findings [ 29 30 31 32 ] . These results illustrate interactions between androgen and retinoid in the control of LNCaP cell growth.
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