Words similar to anti-proliferative
Example sentences for: anti-proliferative
How can you use “anti-proliferative” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, mouse embryonal stem (ES) cells with homozygous deletion of the PTEN gene exhibit increased anchorage-independent growth as compared to normal ES cells [ 12 ] . Similarly, transfer of a wild type PTEN gene into anchorage-independent human glioblastoma cells (which lack functional PTEN), results in their greatly reduced ability to form colonies in soft agar [ 4 5 6 ] . The interpretation of these latter findings, however, is complicated by the strong anti-proliferative effects of PTEN even in monolayer culture, which is consistently observed when the wild type version of this gene is introduced into PTEN-negative tumor cells [ 4 6 7 8 9 10 18 33 ] . Moreover, in human glioma and breast cancer cell lines, the ectopic expression of wild type PTEN leads to anoikis, which is apoptosis initiated by the disruption of cell matrix-interactions [ 23 34 35 36 ] .
These domains interact with p21, CDK2 and CDK4 [ 22 24 25 36 55 ] . Thus, C/EBPα interactions with at least p21 and CDK4 were not required for the anti-proliferative actions of C/EBPα in GHFT1-5 cells.
, showed that Fas might promote T-cell proliferation by modulating release of calcium from intracellular stores [ 38 ] . FasL is anti-proliferative by regulating cell-cycle progression [ 39 ] . Previous studies demonstrated an increase in cell proliferation rates in kidneys of S rats on the high-salt diet [ 7 ] , so it is possible that Fas and FasL may play a role in control of proliferation.
Androgen is essential for normal prostate function, but has also been implicated in the pathogenesis and neoplasia of prostate cancer [ 1 2 26 ] . On the other hand, retinoid is essential for normal prostate function [ 7 27 28 ] and exhibits anti-proliferative and chemopreventive efficacy in experimental prostate carcinoma [ 8 9 10 ] . The dose-dependent stimulation of 3H-thymidine incorporation in LNCaP cells by T and RA when administered alone, and reciprocal suppression of such effects by each other, are consistent with previous findings [ 29 30 31 32 ] . These results illustrate interactions between androgen and retinoid in the control of LNCaP cell growth.
Our finding that 24 h exposure to 4-AP decreased the number of viable GC in serum-free but not serum-supplemented primary cultures is consistent with the reported effects of 4-AP and other K +channel antagonists on other cell types [ 8 43 44 ] . It has been shown that the concentrations of K +channel antagonists required to inhibit growth of human bladder tumor cells can be 70 times higher in the presence than the absence of serum [ 43 ] . 4-AP has been shown to inhibit the proliferation of human myelobastic leukemia cells by preventing growth factor activation of mitogen activated protein kinase (MAPK) pathways [ 42 ] . This mechanism may be responsible for the anti-proliferative effect of 4-AP manifest in Table 1. It is likely that MAPK pathways are less robust in GC grown in defined serum-free vs. serum-supplemented media; however, validation of this hypothesis would require additional experiments beyond the scope of the present investigation.
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