Example sentences for: anti-osteoclastogenic

How can you use “anti-osteoclastogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These results imply a model for arthritic joints in which macrophage precursors entering an inflamed joint are exposed to RANKL and are subsequently rendered resistant to the anti-osteoclastogenic effects of IFN-γ expressed by activated T cells in the synovium.

  • RANKL-pretreated RAW cells are resistant to the anti-osteoclastogenic effect of IFN-γ

  • The resolution of this issue is further clouded by the apparent contradictory findings that IFN-γ is an extremely potent anti-osteoclastogenic factor [ 38 ] but it can be found at high levels in sites of osteolysis [ 39 ] . To reconcile this controversy we performed a series of experiments aimed at understanding how IFN-γ could induce either bactericidal effects via macrophage activation or osteoclastic bone resorption, by influencing the same progenitor cell in the same bone environment.

  • Furthermore, several clinical studies have failed to demonstrate efficacy of IFN-γ administration as an anti-osteoclastogenic agent to prevent bone loss [ 28 29 30 ] . There seem to be situations in which IFN-γ does not act as an anti-osteoclastogenic agent.

  • There are situations, however, in which the anti-osteoclastogenic effects of IFN-γ are not so clear.


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