Words similar to aneuploidy
Example sentences for: aneuploidy
How can you use “aneuploidy” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although numerous hypotheses have been proposed to describe the etiology of aneuploidy in human gametes, the only steadfast association remains maternal age [ 1 2 ] . Besides this association, very little information is available about the numerous potential mechanisms that may disrupt normal chromosome segregation in oocytes.
It may not be coincidental that BRCA1 -mutant breast cancers are preferentially linked to a 'specific' histopathologic pattern that includes a high S-phase fraction of cells, aneuploidy, and hormone receptor-negative status [ 45].
Based on studies involving compounds that alter microtubular kinetics and induce both cell-cycle delay and aneuploidy, several groups have proposed that temporal perturbations during mammalian oocyte maturation (OM) predispose oocytes to aneuploidy [ 3 4 5 6 ] . In addition to faulty microtubule kinetics, perturbations during OM may also stem from abnormal function of centrosomes, kinetochores, spindle checkpoints proteins, the anaphase-promoting complex (APC), the securin-separin-cohesion complex proteins, and the proteasome [ 7 ] .
The origin of single, unpaired chromatids in MII oocytes has been proposed to result from premature separation of sister chromatids prior to anaphase I [ 56 57 ] . The possibility exists that both SC and aneuploidy may have originated from PCS of homologues and sister chromatids during the MAT of meiosis I. Upon removal of MG-132 from the culture media during meiosis I and the subsequent resumption of OM and proteasomal activity, faulty kinetochore-microtubule attachment accompanied by degradation of cohesion proteins could conceivably lead to PCS of homologues and sister chromatids.
The frequencies of hyperploid cells were used as a measure of aneuploidy because an unknown proportion of the hypoploid cells is influenced by technical artifact resulting from excessive chromosome scatter during slide preparation.
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