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Example sentences for: and-
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Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
A recent report demonstrated that S. aureus -induced apoptosis of epithelial cells involves activation of caspases-8 and-3 [ 30 ] . To determine whether caspase-8 is activated in S. aureus -infected osteoblasts, cultured normal mouse osteoblasts were infected with S. aureus strain UAMS-1 at various MOIs.
The enzyme diuses to the A-and-B-laden region of the membrane and binds stereospecifically to the transition state leading from A and B to the products C and D. By binding the transition state complex of this reaction pathway, the enzyme lowers the potential barrier for the A + B ÷ C + D reaction, and the chemical energy stored in A + B is released to form C + D.
Rat T1R2/T1R3 recognized sweet-tasting molecules as diverse as acesulfame-K, dulcin, NC00174 (GA2), saccharin, SC45647 (GA1) and sucrose [ 6 ] , and mT2R-8 and-5 responded to the bitter compounds denatonium, 6-n-propyl-2-thiouracil and cycloheximide respectively [ 17 ] . Thus, although it is clear that the murine taste world in many ways differs from that of humans, the taste of the compounds used here to the mouse seems to be similar to their taste in human.
Austin Room (these days B-and-B rooms are named, not numbered), I opened my book to read and out fluttered the chant.
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