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Example sentences for: anakinra

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IL-1 has been implicated as a pathogenic mediator in numerous inflammatory and degenerative conditions, including rheumatoid arthritis (RA) and osteoarthritis (OA) [ 1 ] . The IL-1 receptor antagonist (IL-1Ra), a naturally occurring inhibitor of the biologic actions of IL-1, has obvious therapeutic potential in such diseases [ 2 ] ; indeed recombinant human IL-1Ra (anakinra) has recently been approved for use in patients with RA as the drug Kineret™ (Amgen, Inc., Thousand Oaks, CA, USA).
Indeed, it is known that anakinra, the recombinant form of human IL-1Ra, differs from its naturally occurring counterpart by possessing an additional amino-terminal methionine residue and lacking glycosylation [ 26 ] . In the first part of the present study similar end-point levels of transgenic and recombinant IL-1Ra were necessary to inhibit fully the response of synoviocytes to a single challenge with IL-1β.