Words similar to anabolic
Example sentences for: anabolic
How can you use “anabolic” in a sentence? Here are some example sentences to help you improve your vocabulary:
These data are in general agreement with studies in both rats and canines that calculate peak serum levels of SVS-OH at 40-60 minutes after gavage administration [ 18 ] . Thus, although we failed to document any bone anabolic activity of SVS in a mouse model of OVX-induced osteoporosis, LC/MS analysis of the SVS-OH metabolite in mouse serum document the efficacy of our gavage administration of SVS to experimental mice.
For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.
failed to detect any anabolic activity of statins in bone and suggested that the disruption of the capillary integrity and local bleeding might explain some of the previously reported bone responses [ 26 ] .
We have recently reported the anabolic action of PTH in an ovariectomized (OVX) Swiss-Webster mouse model, which like the rat model, displays a substantial amount of trabecular bone in its femoral metaphyses and a quantifiable loss of bone following OVX [ 11 ] . The aim of this study was to investigate the effect of simvastatin on the microarchitecture of bone in an established mouse model of osteoporosis, and compare its anabolic action with PTH.
This Swiss-Webster outbred mouse strain utilized in this study has proven to be a valuable model for investigating the efficacy of both anabolic and anti-resorptive therapies for the treatment of osteoporosis.
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