Example sentences for: anabolic

How can you use “anabolic” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.

  • Such a decrease in collagen type I half-life is likely to reflect a significant imbalance between anabolic and catabolic processes at the focal area of metastatic invasion [ 11 ] .

  • Metastatic bone cancer will also affect the balance between the anabolic and catabolic processes at the local site of invasion.

  • We have recently reported the anabolic action of PTH in an ovariectomized (OVX) Swiss-Webster mouse model, which like the rat model, displays a substantial amount of trabecular bone in its femoral metaphyses and a quantifiable loss of bone following OVX [ 11 ] . The aim of this study was to investigate the effect of simvastatin on the microarchitecture of bone in an established mouse model of osteoporosis, and compare its anabolic action with PTH.

  • Due to the potential clinical impact of statins as a treatment option for patients with low bone mass and osteoporosis, it is essential to evaluate its anabolic activity in several in vitro and experimental animal models.


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