Words similar to amide
Example sentences for: amide
How can you use “amide” in a sentence? Here are some example sentences to help you improve your vocabulary:
GSPS is a bifunctional enzyme: its synthase domain carries out the ATP-dependent fusion of two glutathione moieties to the polyamine spermidine to form the antioxidant metabolite GSP, while its amidase domain hydrolyzes the amide linkage to release glutathione and spermidine [ 26, 55, 56].
Of these, the strand that immediately follows the strand with the conserved histidine, contains a conserved polar residue (either histidine or an acidic or amide residue).
Less strong Lewis bases are the charge-compensated Glu in an ion-pair with Arg, the amide group of Gln and Asn, and finally the carbonyl of the peptide backbone as the weakest [ 29 ] . The importance of the ligand was demonstrated by substitution of His with the weaker Lewis base Asn in the apoprotein of the bacterial light-harvesting complex LH1, which eliminated assembly of the complex in vivo and reconstitution in vitro [ 30 ] . Formation of a stable coordination bond with a weaker Lewis base is expected to require a stronger Lewis acid.
As GshA has a binding site that accommodates γ-Glu-Cys, it would appear to be an ideal progenitor of GshB, which uses γ-Glu-Cys as a substrate and also catalyzes the ATP-dependent formation of an amide bond.
It is unlikely that γ-Glu-Cys would have been available because formation of the high-energy amide bond would be unlikely to occur abiotically.
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