Words similar to amelioration
Example sentences for: amelioration
How can you use “amelioration” in a sentence? Here are some example sentences to help you improve your vocabulary:
Once in the tissue, monocytes undergo the poorly understood process of transformation to macrophages with altered morphology and function [ 19 ] . In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20 ] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8 ] . It has therefore been suggested that therapies for chronic arthritis should be aimed at depleting joint mononuclear cells or controlling the activation of synovial macrophages [ 21 ] . Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22 ] and antigen-induced arthritis [ 23 ] induces amelioration of the arthritis.
It is expected that LGT would most easily be recognized if it occurred relatively recently before passage of sufficient time for amelioration of alien characteristics to those of the host genome, for example GC content.
"[D]espite the impossible circumstances under which they were written, they are an extraordinary and moving record of a courageous, compassionate and obstinate mind dedicated to democratic principles and the amelioration of the Chinese people's harsh fate" (Judith Shapiro, the New York Times Book Review ).
However, analyses in which synteny and phylogenetic information were also considered suggest that codon bias and G+C content are poor indicators of HGT [ 45 ] . A role for 'amelioration', whereby structural characteristics of the foreign gene are eventually homogenized to resemble those of the recipient species, has been assumed, but the rate was postulated to be the same as the rate of random, forward mutation [ 42 ] . In addition to alterations in codon usage (as reflected in G+C content), for a bacterial gene to function efficiently in a nematode presumably requires acquisition of regulatory elements (including a promoter) and structural elements (including a poly(A) tail and, optionally, a trans -spliced leader).
Presumably, it was sufficiently recent that significant amelioration to the genomic GC content has not yet occurred.
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