Example sentences for: amelioration

How can you use “amelioration” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Moreover, induction of Th2 cells in a Th1-mediated disease model of collagen-induced arthritis led to amelioration of autoimmune disease [ 16].

  • Presumably, it was sufficiently recent that significant amelioration to the genomic GC content has not yet occurred.

  • "[D]espite the impossible circumstances under which they were written, they are an extraordinary and moving record of a courageous, compassionate and obstinate mind dedicated to democratic principles and the amelioration of the Chinese people's harsh fate" (Judith Shapiro, the New York Times Book Review ).

  • 5B) would be expected to lead to significant amelioration of obese phenotypes, consistent with effects of adrenalectomy on other forms of obesity [ 3 4 5 6 7 ] . Indeed adrenalectomy initially led to a greater loss of body weight after surgery in the diet-induced obese mice (results in text above).

  • Once in the tissue, monocytes undergo the poorly understood process of transformation to macrophages with altered morphology and function [ 19 ] . In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20 ] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8 ] . It has therefore been suggested that therapies for chronic arthritis should be aimed at depleting joint mononuclear cells or controlling the activation of synovial macrophages [ 21 ] . Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22 ] and antigen-induced arthritis [ 23 ] induces amelioration of the arthritis.


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