Example sentences for: amelioration

How can you use “amelioration” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 5B) would be expected to lead to significant amelioration of obese phenotypes, consistent with effects of adrenalectomy on other forms of obesity [ 3 4 5 6 7 ] . Indeed adrenalectomy initially led to a greater loss of body weight after surgery in the diet-induced obese mice (results in text above).

  • However, analyses in which synteny and phylogenetic information were also considered suggest that codon bias and G+C content are poor indicators of HGT [ 45 ] . A role for 'amelioration', whereby structural characteristics of the foreign gene are eventually homogenized to resemble those of the recipient species, has been assumed, but the rate was postulated to be the same as the rate of random, forward mutation [ 42 ] . In addition to alterations in codon usage (as reflected in G+C content), for a bacterial gene to function efficiently in a nematode presumably requires acquisition of regulatory elements (including a promoter) and structural elements (including a poly(A) tail and, optionally, a trans -spliced leader).

  • Once in the tissue, monocytes undergo the poorly understood process of transformation to macrophages with altered morphology and function [ 19 ] . In arthritis, synovial macrophages might cause joint destruction by differentiating to bone-resorbing osteoclasts [ 20 ] or by releasing cartilage-degrading enzymes and cytokines, such as interleukin-1 and tumor necrosis factor-α [ 8 ] . It has therefore been suggested that therapies for chronic arthritis should be aimed at depleting joint mononuclear cells or controlling the activation of synovial macrophages [ 21 ] . Indeed, elimination of macrophages by clodronate-laden liposomes in rat models of adjuvant [ 22 ] and antigen-induced arthritis [ 23 ] induces amelioration of the arthritis.

  • Although many articles, theoretical essays, and books have been written about metaphors, little effort has been made to investigate them systematically: as all of language is itself a metaphor (unless one believes in logomancy), one is continually confronted in the compilation of an ordinary dictionary with examples of semantic and linguistic changes (as well as amelioration, pejoration, etc.) that are tantamount to shifts of meaning that, loosely, could be said to be metaphoric.

  • "[D]espite the impossible circumstances under which they were written, they are an extraordinary and moving record of a courageous, compassionate and obstinate mind dedicated to democratic principles and the amelioration of the Chinese people's harsh fate" (Judith Shapiro, the New York Times Book Review ).


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