Words similar to alkb
Example sentences for: alkb
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The conservation of all the residues implicated in catalysis in the biochemically uncharacterized proteins such as AlkB, EGL-9, leprecan and YbiX suggests they all catalyze oxidative reactions similar to those catalyzed by IPNS, DAOCS, CAS and related enzymes such as protein lysyl/prolyl hydroxylases, EFE and leucoanthocyanidin oxidases [ 1, 2].
The connection between nucleic acid methylation and the AlkB homologs described here is supported by the domain architecture of a conserved pair of animal proteins (C14B1.
Recent studies have shown that AlkB is required for specifically processing lesions resulting from the alkylation of single-stranded (ss) DNA [ 18].
The clavaminic acid synthase, an outlier of this latter family, has its own characteristic inserts, including a giant (approximately 70 amino acids) insert between strands 4 and 5 [ 8], and some members of the AlkB family have smaller inserts in the same position (Figure 1).
In the case of the AlkB family, a single horizontal transfer event probably resulted in their entry into the eukaryotic lineage, which was followed by adaptation to new, RNA-related roles by some paralogs.
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