Words similar to alkb
Example sentences for: alkb
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In this context, it should be noted that the DNA-repair proteins typified by E. coli AlkB are unrelated to the alkane omega-hydroxylase typified by the Ps.
In particular, we propose a specific mechanism of action in DNA repair, and possibly in RNA modification, for the AlkB protein and its homologs.
In the case of the AlkB family, a single horizontal transfer event probably resulted in their entry into the eukaryotic lineage, which was followed by adaptation to new, RNA-related roles by some paralogs.
For example, the insert between the fifth and sixth strand in AlkB is predicted to contain an extra strand, whereas in the small-molecule dioxygenase (IPNS/ethylene-forming enzyme (EFE)) family, the same region forms (or is predicted to form) a short helix (Figures 1, 3).
The conservation of all the residues implicated in catalysis in the biochemically uncharacterized proteins such as AlkB, EGL-9, leprecan and YbiX suggests they all catalyze oxidative reactions similar to those catalyzed by IPNS, DAOCS, CAS and related enzymes such as protein lysyl/prolyl hydroxylases, EFE and leucoanthocyanidin oxidases [ 1, 2].