Words similar to alkb
Example sentences for: alkb
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AlkB binds ssDNA and is required for the processing of toxic DNA modifications caused by SN2 alkylating agents such as methylmethanesulfonate (MMS) specifically on ssDNA.
In the case of the AlkB family, a single horizontal transfer event probably resulted in their entry into the eukaryotic lineage, which was followed by adaptation to new, RNA-related roles by some paralogs.
Recent studies have shown that AlkB is required for specifically processing lesions resulting from the alkylation of single-stranded (ss) DNA [ 18].
Such modifications might also be used in the host-mediated inactivation of viral RNAs, and the AlkB homologs acquired by some plant viruses could counter this host-defense mechanism.
The clavaminic acid synthase, an outlier of this latter family, has its own characteristic inserts, including a giant (approximately 70 amino acids) insert between strands 4 and 5 [ 8], and some members of the AlkB family have smaller inserts in the same position (Figure 1).
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