Example sentences for: alk

How can you use “alk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • ALK3 (Z22535), and

  • However, transgenic frogs carrying a hyperactive form of Msx1 or constitutively active ALK3 (a receptor for BMP4) are able to regenerate their tails during the refractory period.

  • It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .

  • Thus, the ALK3Q233D-induced degradation of SNIP1 is regulated by the protein levels of Smad1, Smad4, Az and is only induced by high dose of the activated BMP type I receptor.

  • The lower levels of Smad1, Smad4, Az and SNIP1 in lane 1 compared with those in lane 10 suggest that the leaky signaling by the overexpressed ALK3, which we have demonstrated recently [ 39 ] , caused a constitutive reduction of Smad4, Az and SNIP1 level that is dependent upon the activation of Smad1.


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