Example sentences for: alk

How can you use “alk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Thus, the ALK3Q233D-induced degradation of SNIP1 is regulated by the protein levels of Smad1, Smad4, Az and is only induced by high dose of the activated BMP type I receptor.

  • The interaction was diminished when cells were co-transfected with the activated BMP type I receptor ALK3Q233D (Fig.

  • To follow the observed reduction of SNIP1 level upon the expression of high level of ALK3Q233D, as mentioned above, we co-expressed SNIP1 together with Smad1, Smad4, Az and high dose (6 μg) of either the wild type ALK3 or the constitutive active ALK3Q233D.

  • First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.

  • The ability of Smad1 in regulating SNIP1 degradation was further demonstrated by increased expression of Smad1 in COS1 cells that were transfected with a constant amount of Smad4, Az, ALK3Q233D and SNIP1 (Fig.


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