Example sentences for: alk

How can you use “alk” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.

  • The Mouse Genome Informatics (http://www.informatics.jax.org/) accession numbers of the genes discussed in this paper are ALK3 (MGI: 1338938), BMP4 (MGI: 88180), Msx1 (MGI: 97168), and Notch1 (MGI: 97363).

  • ALK3 (Z23154).

  • The ALK3Q233D-induced degradation of SNIP1 was significantly blocked in the absence of Az (Fig.

  • We tested the localization of endogenous HsN3 in COS1 cell line, which was transiently transfected with Smad1, ALK3 and the BMP type II receptor.


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