Words similar to alk

Example sentences for: alk

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In the absence of ALK3Q233D, no F-Az was detected in the precipitates of SNIP1 (Fig.
First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.
6E), we therefore tested Az interaction with SNIP1 in the presence of the co-expression of Smad1, Smad4 and ALK3Q233D.
However, when HsN3 was co-expressed with both Smad1 and ALK3Q233D, the majority of HsN3 signals were detected in the nucleus (Fig.
The interaction was diminished when cells were co-transfected with the activated BMP type I receptor ALK3Q233D (Fig.