Words similar to aldh

Example sentences for: aldh

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Although ALDH1A2 appears only to catalyze the oxidation of all-trans retinal to all-trans retinoic acid, both ALDH1A1 and CYP1 and CYP3A [ 34 ] enzymes are capable of oxidizing 9-cis retinal to 9-cis retinoic acid.
Seventeen ALDH genes have been identified in the human genome and have been classified into ten different families based on amino acid sequence identities [ 1 2 ] . High levels of ALDH1A1 activity can protect human and murine cells from the toxicity of the alkylating agent cyclophosphamide and its oxazaphosphorine analogs.
In vitro, purified mouse [ 11 ] , human [ 12 ] , and Xenopus [ 13 ] ALDH1A1 can efficiently oxidize all-trans retinal to all-trans retinoic acid.
We have identified 4-(N, N-dipropylamino)benzaldehyde (DPAB) (Figure 1B) and 4-(N, N-diethylamino) benzaldehyde (DEAB) as potent, selective inhibitors of ALDH1A1, but not ALDH2 or ALDH3, with the dipropyl analog exhibiting 10-fold greater efficacy for inhibition [ 19 20 ] . The effect of DPAB on ALDH1A2 has not been reported.
In addition, our results indicate that in HL60 cells, the prototype cell line for studying retinoic acid induced cell differentiation, ALDH1A1 is not the operative oxidizing enzyme for retinal.