Example sentences for: aldh

How can you use “aldh” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Our long-term goal is to use DPAB to investigate the role of ALDH1A1 in retinoic acid biosynthesis at different stages of hematopoiesis.

  • DPAB is a potent inhibitor of retinal oxidation with IC 50 values of 0.11 and 0.13 μM for purified mouse and human ALDH1A1, respectively (Table 1).

  • Treatment of L1210/CPA cells in vitro with 50 μM DEAB abolished the tumor cells' resistance to 4-HC [ 19 ] . DEAB also exhibited in vivo efficacy as a ALDH1A1 inhibitor, as demonstrated by the toxicity to the intestinal crypt cells in mice receiving co-injections of DEAB and cyclophosphamide [ 21 ] . More recently, DEAB has been used to demonstrate that overexpression of human ALDH1A1 in transfected cell lines is sufficient to cause cellular resistance to the oxazaphosphorines [ 22 ] and 4-HC [ 23 ] . DEAB has also been an effective reagent in fluorescent-activated cell sorting (FACS) techniques to isolate human hematopoietic stem cells based on the expression of ALDH1A1 activity [ 5 6 ] . In contrast to DEAB and DPAB, daidzin - a natural product isolated from Pueraria lobata (the Kudzu plant) - shows specificity for inhibiting ALDH2 at concentrations similar to that of DPAB used to inhibit ALDH1A1 [ 24 25 ] . An inhibitor specific for ALDH1A2 has not yet been reported.

  • In vivo , the introduction of ALDH1A1 mRNA into Xenopus embryos induces early synthesis of retinoic acid, while ALDH1A1 expression is detected during the tail bud stages of Xenopus embryogenesis [ 14 ] . ALDH1A2 in the mouse [ 15 ] and rat [ 16 ] has shown even greater specificity and catalytic efficiency for retinal as a substrate.

  • ALDH1A1 activity was measured on a Shimadzu UV1201 Spectrophotometer at 36.


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