Words similar to aldh

Example sentences for: aldh

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DPAB is a potent inhibitor of retinal oxidation with IC 50 values of 0.11 and 0.13 μM for purified mouse and human ALDH1A1, respectively (Table 1).
Indeed it was hypothesized that the high expression of ALDH1A1 (formerly known as class 1 ALDH) was responsible for the successful use of cyclophosphamide in tumor cell purging regimens during bone marrow transplantation [ 3 ] . The detection of elevated ALDH1A1 activity in the most primitive human hematopoietic progenitor cells [ 4 5 6 ] has provided evidence in support of this hypothesis.
Therefore, though low levels of ALDH1A1 activity have been reported in HL-60 cells in previous studies [ 5 31 ] , it appears that the differentiation observed in cells exposed to retinal alone or retinal plus DPAB was not mediated by ALDH1A1 oxidation of retinal to retinoic acid.
In vivo , the introduction of ALDH1A1 mRNA into Xenopus embryos induces early synthesis of retinoic acid, while ALDH1A1 expression is detected during the tail bud stages of Xenopus embryogenesis [ 14 ] . ALDH1A2 in the mouse [ 15 ] and rat [ 16 ] has shown even greater specificity and catalytic efficiency for retinal as a substrate.
The purification of ALDH1A1 from mouse liver and human erythrocytes was performed as in [ 20 ] .