Words similar to aldh

Example sentences for: aldh

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Although ALDH1A2 appears only to catalyze the oxidation of all-trans retinal to all-trans retinoic acid, both ALDH1A1 and CYP1 and CYP3A [ 34 ] enzymes are capable of oxidizing 9-cis retinal to 9-cis retinoic acid.
Immuno-histochemical analysis of mouse embryos shows that ALDH1A1 expression occurs primarily in cranial tissues, while ALDH1A2 expression occurs primarily in trunk tissue [ 17 ] . In addition, the targeted knockout of the ALDH1A2 gene in mice results in a significant decrease in retinoic acid biosynthesis and early embryo death [ 18 ] .
In addition, expression of CYP1A1 and CYP3A4 mRNA has been reported in HL-60 cells [ 36 ] . The contribution of ALDH1A2 also can't be ruled out.
ALDH activity has been reported in HL-60 cells using 4-hydroxynonenal as substrate [ 32 ] . However, since this molecule is such a poor substrate with ALDH1 compared to ALDH3, the measured activity likely represents only ALDH3 activity.
The development of inhibitors which can target individual ALDH enzymes provides one approach for addressing the role of a specific ALDH enzyme in the oxidation of retinal to retinoic acid in a given cell type.