Example sentences for: aldh

How can you use “aldh” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The report of the crystal structure of the homotetrameric ALDH1A1 enzyme from sheep liver revealed a substrate tunnel capable of binding retinal which was absent in ALDH2 and ALDH3A1 enzymes [ 9 ] . Likewise, the crystal structure reported for mouse ALDH1A2 revealed a substrate channel which could provide specificity for retinal and exclude short-chain aliphatic aldehydes [ 10 ] .

  • In addition, expression of CYP1A1 and CYP3A4 mRNA has been reported in HL-60 cells [ 36 ] . The contribution of ALDH1A2 also can't be ruled out.

  • The development of inhibitors which can target individual ALDH enzymes provides one approach for addressing the role of a specific ALDH enzyme in the oxidation of retinal to retinoic acid in a given cell type.

  • Therefore, we chose the HL-60 cell line to assess the role of ALDH1A1 in the oxidation of retinal.

  • Indeed it was hypothesized that the high expression of ALDH1A1 (formerly known as class 1 ALDH) was responsible for the successful use of cyclophosphamide in tumor cell purging regimens during bone marrow transplantation [ 3 ] . The detection of elevated ALDH1A1 activity in the most primitive human hematopoietic progenitor cells [ 4 5 6 ] has provided evidence in support of this hypothesis.


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