Words similar to aldh
Example sentences for: aldh
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We have identified 4-(N, N-dipropylamino)benzaldehyde (DPAB) (Figure 1B) and 4-(N, N-diethylamino) benzaldehyde (DEAB) as potent, selective inhibitors of ALDH1A1, but not ALDH2 or ALDH3, with the dipropyl analog exhibiting 10-fold greater efficacy for inhibition [ 19 20 ] . The effect of DPAB on ALDH1A2 has not been reported.
Several enzymes, including isoforms of alcohol dehydrogenase, ALDH, and cytochrome P450 (CYP), recently have been shown to be involved in the formation of retinoic acid from retinol and retinal [ 7 8 ] . The purification, cloning, and characterization of several ALDH enzymes which efficiently catalyze the oxidation of retinal (Figure 1A) has suggested that regulation of retinoic acid formation could be a key physiologic role for these enzymes.
Indeed it was hypothesized that the high expression of ALDH1A1 (formerly known as class 1 ALDH) was responsible for the successful use of cyclophosphamide in tumor cell purging regimens during bone marrow transplantation [ 3 ] . The detection of elevated ALDH1A1 activity in the most primitive human hematopoietic progenitor cells [ 4 5 6 ] has provided evidence in support of this hypothesis.
DPAB is a potent inhibitor of retinal oxidation with IC 50 values of 0.11 and 0.13 μM for purified mouse and human ALDH1A1, respectively (Table 1).
In vivo , the introduction of ALDH1A1 mRNA into Xenopus embryos induces early synthesis of retinoic acid, while ALDH1A1 expression is detected during the tail bud stages of Xenopus embryogenesis [ 14 ] . ALDH1A2 in the mouse [ 15 ] and rat [ 16 ] has shown even greater specificity and catalytic efficiency for retinal as a substrate.
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