Example sentences for: aldehyde

How can you use “aldehyde” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Several of the differentially expressed genes, including aldo-keto reductase 1C1 ( AKR1C1 ), aldehyde dehydrogenase 1A1 ( ALDH1A1 ), and alcohol dehydrogenase 1B ( ADH1B ), function in sex steroid and retinoic acid metabolism (Figure 2).

  • Besides inhibiting proteasome activity, the peptide aldehyde proteasome inhibitors have been also reported to repress certain lysosomal cysteine proteases and calpains [ 49 ] . The finding that MG-132 can obstruct the casein degrading activity of the calcium-dependent protease calpain [ 50 ] appears relevant to oocyte maturation.

  • MG-132 is a peptide aldehyde that inhibits ubiquitin-mediated proteolysis by binding to and inactivating 20S and 26S proteasomes [ 49 62 ] . Although 1-10 μM MG-132 inhibited first polar body extrusion in rat oocytes, its activity is reversible [ 42 ] . We conducted preliminary experiments to obtain a MG-132 dose range that would transiently perturb or inhibit OM during meiosis I while enabling oocytes to complete OM following washing out of the compound.

  • The peptide aldehyde proteasome inhibitors MG132 and ALLN have previously been used to investigate the post-transcriptional regulation of proteins during physiological processes [ 52, 53].

  • Both MAP kinase and STAT pathways are involved in AR-dependent regulation and in ligand-independent activation of the AR [ 18 ] . Differential expression of aldehyde dehydrogenase 1A1 and alcohol dehydrogenase 1B, enzymes that affect retinoic acid biosynthesis, suggest that other signaling pathways may participate in the AR-initiated programs of external genital differentiation [ 19 20 ] .


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