Words similar to aicd

Example sentences for: aicd

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Cao and Sudhof [56] have recently discovered that the APP C-terminal fragment generated by α- or β-secretase is itself cleaved to release Aβ and an APP intracellular domain (AICD) that diffuses into the nucleus, possibly acting there as a transcription factor.
In induced models of autoimmunity, the CD28-B7 interaction has been shown to regulate disease susceptibility by rendering autoreactive T cells anergic, or alternatively by upregulating the threshold for autoreactive T-cell activation [ 30 ] . Furthermore, we previously showed that impaired Fas-mediated activation-induced cell death (AICD) of autoreactive T-helper-1 cells may be responsible for the development of PGIA [ 20 ] . Therefore, AICD and/or T-cell anergy, but not the CD4 +CD25 +regulatory T cells, may be responsible for deletion or inactivation of autoreactive T cells in autoimmune arthritis.
AICD = activation-induced cell death; CTLA = cytotoxic T-lymphocyte antigen; ELISA = enzyme-linked immunosorbent assay; FITC = fluorescein isothiocyanate; IL = interleukin; PE = R-phycoerythrin; PG = proteoglycan; PGIA, proteoglycan-induced arthritis; SCID = severe combined immunodeficient; TCR = T-cell receptor; TGF = transforming growth factor; WT = wild-type.
The pathway leading to AICD must be initiated by ectodomain shedding: holoAPP cannot directly give rise to AICD.
Therefore, one important function for α- and/or β-secretase processing of APP may be the eventual generation of AICD.