Words similar to agrin
Example sentences for: agrin
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Both agrin, LN1, and combinations of the two significantly increased aggregate size (Figure 2C).
Whether or not the effects of LN1 on aggregation dynamics can all be attributed to an increase in receptor expression, it seems clear from several lines of evidence that the mechanism is distinct from that of agrin induction, and that the physiological effects of laminin are permissive rather than instructive for receptor aggregation.
Laminins are major components of the extracellular matrix and exist in many isoforms with varying functions including cell adhesion, neurite outgrowth, and cellular signaling [ 7 8 9 10 ] . Laminin binds agrin [ 11 ] , and colocalizes with AChR aggregates [ 12 13 14 ] . It also binds with α-Dystroglycan (α-DG), an important part of the dystrophin/utrophin glycoprotein complex (Reviewed in [ 15 16 ] ). The dystrophin complex is also found concentrated at the neuromuscular junction with AChRs and laminin, and for this and other reasons is thought to be involved in both formation and maintenance of the NMJ [ 2 17 18 19 20 21 22 23 ] .
The observed receptor aggregates were found to be significantly different from random only with agrin alone as the stimulus, in which case they were found closer together, indicating spatial cooperativity.
Examples of the effects of agrin and LN1 alone or in combination using these protocols are shown in Figure 1. It is clear from visual inspection that either stimulus, or the stimuli together, increase the prominence of receptor aggregates (Figure 1Avs.
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