Example sentences for: agrin

How can you use “agrin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • [ 5 ] . BDNF transiently stabilizes silent NM synapses during the period of transition from polyneuronal to mononeuronal innervation of skeletal muscle fibers [ 6 ] . BDNF and CNTF cooperatively affect efficiency of embryonic xenopus neuromuscular synapses in culture [ 7 8 ] . BDNF stimulates transmitter release from neuromuscular synapses [ 9 ] and enhances the efficiency of transmission at the neuromuscular synapse [ 10 ] . BDNF, together with NT-3, can restore neuregulin levels and a normal distribution of AchR at the neuromuscular junction blocked with curare [ 11 ] . BDNF, in conjunction with fibronectin, increases spontaneous synaptic currents in the cultured embryonic xenopus neuromuscular junction [ 12 ] . BDNF down-regulates AchR clustering, most likely by binding to TrkB expressed in myocytes [ 13 ] . BDNF downregulates agrin levels in muscle but increases neuregulin in ventral horn spinal motor neurons at the time when they form neuromuscular synapses [ 14 ] .

  • Both of these findings suggest distinct pathways for agrin and laminin induced receptor aggregation, and this conclusion is strengthened by the observation laminin, unlike agrin, dramatically increased the density of receptors within aggregates (Figure 2D), as reported previously [ 1 ] . The independence of pathways is also indicated by the profoundly different effects of the two stimuli on aggregate distribution.

  • However, several other researchers have reported that laminins including laminin-1 (LN1) also induce receptor aggregation in cultured mouse muscle cells [ 1 2 3 ] . At this time the LN1 stimulation pathway is not well understood, but it has been argued from several lines of evidence to be at least partially distinct from the agrin pathway.

  • Average receptor expression was found to be significantly increased following exposure to agrin, and less so although still significantly in response to LN1 (Figure 2A).

  • Laminins are major components of the extracellular matrix and exist in many isoforms with varying functions including cell adhesion, neurite outgrowth, and cellular signaling [ 7 8 9 10 ] . Laminin binds agrin [ 11 ] , and colocalizes with AChR aggregates [ 12 13 14 ] . It also binds with α-Dystroglycan (α-DG), an important part of the dystrophin/utrophin glycoprotein complex (Reviewed in [ 15 16 ] ). The dystrophin complex is also found concentrated at the neuromuscular junction with AChRs and laminin, and for this and other reasons is thought to be involved in both formation and maintenance of the NMJ [ 2 17 18 19 20 21 22 23 ] .


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast