Words similar to agrin
Example sentences for: agrin
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Also, while laminin stimulation increased the colocalization of AChRs and αDG in our experiments, agrin also produced a similar increase (Figure 5).
This is based on aggregation assays showing different time courses, additive dose response relationships, and differential co-localization of the dystrophin complex, and on biochemical observations indicating the lack of requirement for MuSK, and the lack of tyrosine-phosphorylation of receptors during LN1 but not agrin induced aggregation [ 1 2 4 ] . The very minimal receptor aggregation seen in agrin deficient mice certainly argues that laminins are not sufficient to trigger receptor aggregation [ 5 ] . More recently we have shown that agrin and LN1 induced aggregates can also be differentiated on the basis of the ultrastructural arrangement of receptors within aggregates [ 6 ] .
Examples of the effects of agrin and LN1 alone or in combination using these protocols are shown in Figure 1. It is clear from visual inspection that either stimulus, or the stimuli together, increase the prominence of receptor aggregates (Figure 1Avs.
Average receptor expression was found to be significantly increased following exposure to agrin, and less so although still significantly in response to LN1 (Figure 2A).
In the present experiments the trends are all quite similar, however, and are shown in Figure 5. All correlation measures show progressive and significant increases from control to agrin to LN1 to agrin/LN1.
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