Words similar to aggresome-like

Example sentences for: aggresome-like

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The following results support this hypothesis: 1) sα i2 and α i2 are equally labeled by a pulse of 3H-myristate, although much less sα i2 protein is detected; 2) sα i2 displays a propensity to localize to potential aggresome-like structures, and this localization is greatly enhanced by proteasome inhibitor treatment; 3) the α i2 A327S mutant, previously shown to be unstable and defective in guanine-nucleotide binding, shows a similar pattern of subcellular localization ( i.e., intracellular membranes rather than PM); 4) βγ over-expression increases expression of sα i2 and promotes PM localization of sα i2 and α i2 A327S, but βγ co-expression does not prevent sα i2 localization to potential aggresome-like structures when cells are treated with proteasome inhibitors; and 5) pulse-chase analysis indicates that sα i2 is rapidly degraded.
Interestingly, ALLN treatment was relatively ineffective at promoting accumulation of overexpressed α s in aggresome-like structures (not shown).
The observed intracellular membrane (ER) localization and proteasome inhibitor-induced juxtanuclear aggregate accumulation (aggresome) is consistent with that reported for other proteins being degraded by such a pathway [ 18 24 ] . When treated with proteasome inhibitors, overexpressed wild type α i2 also accumulates in aggresome-like structures (Figure 7), suggesting that Gα may normally be degraded by a proteasome-dependent pathway.