Example sentences for: age-dependent

How can you use “age-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We recently published a study of the characteristic hyperthermic responses represented as epileptiform-like population spike activity accompanied by spreading depression (SD) in a rat hippocampal slice, which may serve as an in vitro model of febrile seizures [ 8 ] . The hyperthermic response was age-dependent, occurring almost exclusively in young, but not newborn, rats.

  • Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease that causes progressive motoneuron degeneration, skeletal muscle atrophy, paralysis and death [ 1 2 3 ] . Although clinically indistinguishable, the majority of cases are sporadic (SALS) and approximately 10 % are due to inherited causes (familial ALS or FALS).

  • Using this system, we demonstrated significant strain, gender and age-dependent differences in electrocardiograms in mice.

  • This protective mechanism declines with age because a study analyzing metallothionein levels in RPE of macular region showed a dramatic decrease in aged donors (mean age = 80-yr) as compared to those from younger donors (mean age = 58-yr) [ 36 ] . A separate report concluded that there was also an age-dependent decrease of catalase activity in RPE [ 37 ] . These studies suggest RPE in the elderly are more susceptible to oxidative stress induced damage, which may contribute to age-related RPE dysfunction and vision loss.

  • A subsequent study, demonstrating an age-dependent reduction in HIF-1α activity, provides one explanation for the lower VEGF-A expression in response to hypoxia in aged animals [ 28].


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